TY  - JOUR
AU  - Hartmann, Benedikt
AU  - Müller, Max
AU  - Seyler, Lisa
AU  - Bäuerle, Tobias
AU  - Wilferth, Tobias
AU  - Avdievitch, Nikolai
AU  - Ruhm, Loreen
AU  - Henning, Anke
AU  - Lesiv, Alexei
AU  - Ivashkin, Pavel
AU  - Uder, Michael
AU  - Nagel, Armin
TI  - Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
JO  - PLOS ONE
VL  - 16
IS  - 6
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - DKFZ-2021-01269
SP  - e0252935 -
PY  - 2021
N1  - #LA:E020#
AB  - Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.
LB  - PUB:(DE-HGF)16
C6  - pmid:34097707
DO  - DOI:10.1371/journal.pone.0252935
UR  - https://inrepo02.dkfz.de/record/169124
ER  -