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@ARTICLE{Hartmann:169124,
      author       = {B. Hartmann and M. Müller and L. Seyler and T. Bäuerle
                      and T. Wilferth and N. Avdievitch and L. Ruhm and A. Henning
                      and A. Lesiv and P. Ivashkin and M. Uder and A. Nagel$^*$},
      title        = {{F}easibility of deuterium magnetic resonance spectroscopy
                      of 3-{O}-{M}ethylglucose at 7 {T}esla.},
      journal      = {PLOS ONE},
      volume       = {16},
      number       = {6},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2021-01269},
      pages        = {e0252935 -},
      year         = {2021},
      note         = {#LA:E020#},
      abstract     = {Deuterium Magnetic Resonance Spectroscopy (DMRS) is a
                      non-invasive technique that allows the detection of
                      deuterated compounds in vivo. DMRS has a large potential to
                      analyze uptake, perfusion, washout or metabolism, since
                      deuterium is a stable isotope and therefore does not decay
                      during biologic processing of a deuterium labelled
                      substance. Moreover, DMRS allows the distinction between
                      different deuterated substances. In this work, we performed
                      DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a
                      non-metabolizable glucose analog which is transported
                      similar to D-glucose. DMRS of OMG was performed in phantom
                      and in vivo measurements using a preclinical 7 Tesla MRI
                      system. The chemical shift (3.51 ± 0.1 ppm) and relaxation
                      times were determined. OMG was injected intravenously and
                      spectra were acquired over a period of one hour to monitor
                      the time evolution of the deuterium signal in tumor-bearing
                      rats. The increase and washout of OMG could be observed.
                      Three different exponential functions were compared in terms
                      of how well they describe the OMG washout. A
                      mono-exponential model with offset seems to describe the
                      observed time course best with a time constant of 1910 ±
                      770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N =
                      3). Chemical shift imaging could be performed with a voxel
                      size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS
                      with deuterium labelled OMG could be demonstrated. These
                      data might serve as basis for future studies that aim to
                      characterize glucose transport using DMRS.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34097707},
      doi          = {10.1371/journal.pone.0252935},
      url          = {https://inrepo02.dkfz.de/record/169124},
}