Home > Publications database > Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla. > print

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100 1 _ |a Hartmann, Benedikt
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245 _ _ |a Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.
260 _ _ |a San Francisco, California, US
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520 _ _ |a Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm x 7.1 mm x 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.
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700 1 _ |a Müller, Max
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700 1 _ |a Seyler, Lisa
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700 1 _ |a Bäuerle, Tobias
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700 1 _ |a Wilferth, Tobias
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700 1 _ |a Avdievitch, Nikolai
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700 1 _ |a Ruhm, Loreen
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700 1 _ |a Henning, Anke
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700 1 _ |a Lesiv, Alexei
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700 1 _ |a Ivashkin, Pavel
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700 1 _ |a Uder, Michael
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700 1 _ |a Nagel, Armin
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