TY  - JOUR
AU  - Dossus, Laure
AU  - Kouloura, Eirini
AU  - Biessy, Carine
AU  - Viallon, Vivian
AU  - Siskos, Alexandros P
AU  - Dimou, Niki
AU  - Rinaldi, Sabina
AU  - Merritt, Melissa A
AU  - Allen, Naomi
AU  - Fortner, Renee
AU  - Kaaks, Rudolf
AU  - Weiderpass, Elisabete
AU  - Gram, Inger T
AU  - Rothwell, Joseph A
AU  - Lécuyer, Lucie
AU  - Severi, Gianluca
AU  - Schulze, Matthias B
AU  - Nøst, Therese Haugdahl
AU  - Crous-Bou, Marta
AU  - Sánchez, Maria-Jose
AU  - Amiano, Pilar
AU  - Colorado-Yohar, Sandra M
AU  - Gurrea, Aurelio Barricarte
AU  - Schmidt, Julie A
AU  - Palli, Domenico
AU  - Agnoli, Claudia
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Mattiello, Amalia
AU  - Vermeulen, Roel
AU  - Heath, Alicia K
AU  - Christakoudi, Sofia
AU  - Tsilidis, Konstantinos K
AU  - Travis, Ruth C
AU  - Gunter, Marc J
AU  - Keun, Hector C
TI  - Prospective analysis of circulating metabolites and endometrial cancer risk.
JO  - Gynecologic oncology
VL  - 162
IS  - 2
SN  - 0090-8258
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2021-01281
SP  - 475-481
PY  - 2021
N1  - 2021 Aug;162(2):475-481
AB  - Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC).A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry. Conditional logistic regression estimated the associations of metabolites with endometrial cancer risk. An analysis focusing on clusters of metabolites using the bootstrap lasso method was also employed.After adjustment for body mass index, sphingomyelin [SM] C18:0 was positively (OR1SD: 1.18, 95
KW  - Amino acids (Other)
KW  - Endometrial cancer (Other)
KW  - Lipids (Other)
KW  - Metabolomics (Other)
KW  - Obesity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34099314
DO  - DOI:10.1016/j.ygyno.2021.06.001
UR  - https://inrepo02.dkfz.de/record/169139
ER  -