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000169143 1001_ $$00000-0001-9767-7998$$aDi Castelnuovo, A.$$b0
000169143 245__ $$aAlcohol Intake and Total Mortality in 142,960 Individuals from the MORGAM Project: a population-based study.
000169143 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2022
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000169143 500__ $$a2022 Feb;117(2):312-325
000169143 520__ $$aTo test the association of alcohol consumption with total and cause-specific mortality risk DESIGN: Prospective observational multicentre population-based study SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project PARTICIPANTS: A total of 142,960 individuals (mean age 50±13 y, 53.9% men) MEASUREMENTS: Average alcohol intake by food frequency questionnaire. Total and cause-specific mortality FINDINGS: In comparison with lifetime abstainers, consumption of alcohol less than 10 gr/d was associated with an average 11% (95%CI: 7%-14%) reduction in the risk of total mortality, while intake >20 gr/d was associated with a 13% (7%-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. As far as cancer is concerned, drinking up to 10 gr/d was not associated with either mortality risk reduction or increase, while alcohol intake >20 gr/d was associated with a 22% (10%-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between Countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that HDLc explained 2.9% and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.In comparison with lifetime abstainers, consuming less than 1 drink per day (nadir at 5 gr/d) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than 2 drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
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000169143 7001_ $$00000-0003-4569-1186$$aCostanzo, S.$$b1
000169143 7001_ $$aBonaccio, M.$$b2
000169143 7001_ $$aMcElduff, P.$$b3
000169143 7001_ $$aLinneberg, A.$$b4
000169143 7001_ $$aSalomaa, V.$$b5
000169143 7001_ $$aMännistö, S.$$b6
000169143 7001_ $$aMoitry, M.$$b7
000169143 7001_ $$aFerrières, J.$$b8
000169143 7001_ $$aDallongeville, J.$$b9
000169143 7001_ $$aThorand, B.$$b10
000169143 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, H.$$b11$$udkfz
000169143 7001_ $$aFerrario, M.$$b12
000169143 7001_ $$aVeronesi, G.$$b13
000169143 7001_ $$aPettenuzzo, E.$$b14
000169143 7001_ $$aTamosiunas, A.$$b15
000169143 7001_ $$aNjølstad, I.$$b16
000169143 7001_ $$aDrygas, W.$$b17
000169143 7001_ $$aNikitin, Y.$$b18
000169143 7001_ $$aSöderberg, S.$$b19
000169143 7001_ $$aKee, F.$$b20
000169143 7001_ $$aGrassi, G.$$b21
000169143 7001_ $$aWestermann, D.$$b22
000169143 7001_ $$aSchrage, B.$$b23
000169143 7001_ $$aDabboura, S.$$b24
000169143 7001_ $$aZeller, T.$$b25
000169143 7001_ $$aKuulasmaa, K.$$b26
000169143 7001_ $$aBlankenberg, S.$$b27
000169143 7001_ $$aDonati, M. B.$$b28
000169143 7001_ $$ade Gaetano, G.$$b29
000169143 7001_ $$00000-0003-0514-5885$$aIacoviello, L.$$b30
000169143 7001_ $$aInvestigators, MORGAM Study$$b31$$eCollaboration Author
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