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@ARTICLE{DiCastelnuovo:169143,
      author       = {A. Di Castelnuovo and S. Costanzo and M. Bonaccio and P.
                      McElduff and A. Linneberg and V. Salomaa and S. Männistö
                      and M. Moitry and J. Ferrières and J. Dallongeville and B.
                      Thorand and H. Brenner$^*$ and M. Ferrario and G. Veronesi
                      and E. Pettenuzzo and A. Tamosiunas and I. Njølstad and W.
                      Drygas and Y. Nikitin and S. Söderberg and F. Kee and G.
                      Grassi and D. Westermann and B. Schrage and S. Dabboura and
                      T. Zeller and K. Kuulasmaa and S. Blankenberg and M. B.
                      Donati and G. de Gaetano and L. Iacoviello},
      collaboration = {M. S. Investigators},
      title        = {{A}lcohol {I}ntake and {T}otal {M}ortality in 142,960
                      {I}ndividuals from the {MORGAM} {P}roject: a
                      population-based study.},
      journal      = {Addiction},
      volume       = {117},
      number       = {2},
      issn         = {0965-2140},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2021-01284},
      pages        = {312-325},
      year         = {2022},
      note         = {2022 Feb;117(2):312-325},
      abstract     = {To test the association of alcohol consumption with total
                      and cause-specific mortality risk DESIGN: Prospective
                      observational multicentre population-based study SETTING:
                      Sixteen cohorts (15 from Europe) in the MOnica Risk,
                      Genetics, Archiving and Monograph (MORGAM) Project
                      PARTICIPANTS: A total of 142,960 individuals (mean age
                      50±13 y, $53.9\%$ men) MEASUREMENTS: Average alcohol intake
                      by food frequency questionnaire. Total and cause-specific
                      mortality FINDINGS: In comparison with lifetime abstainers,
                      consumption of alcohol less than 10 gr/d was associated with
                      an average $11\%$ $(95\%CI:$ $7\%-14\%)$ reduction in the
                      risk of total mortality, while intake >20 gr/d was
                      associated with a $13\%$ $(7\%-20\%)$ increase in the risk
                      of total mortality. Comparable findings were observed for
                      cardiovascular (CV) deaths. As far as cancer is concerned,
                      drinking up to 10 gr/d was not associated with either
                      mortality risk reduction or increase, while alcohol intake
                      >20 gr/d was associated with a $22\%$ $(10\%-35\%)$
                      increased risk of mortality. The association of alcohol with
                      fatal outcomes was similar in men and women, differed
                      somewhat between Countries and was more apparent in
                      individuals preferring wine, suggesting that benefits may
                      not be due to ethanol but other ingredients. Mediation
                      analysis showed that HDLc explained $2.9\%$ and $18.7\%$ of
                      the association between low alcohol intake and total as well
                      as CV mortality, respectively.In comparison with lifetime
                      abstainers, consuming less than 1 drink per day (nadir at 5
                      gr/d) was associated with a reduced risk of total,
                      cardiovascular and other causes mortality, except cancer.
                      Intake of more than 2 drinks per day was associated with an
                      increased risk of total, cardiovascular and especially
                      cancer mortality.},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34105209},
      doi          = {10.1111/add.15593},
      url          = {https://inrepo02.dkfz.de/record/169143},
}