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@ARTICLE{Zheng:169168,
      author       = {G. Zheng$^*$ and K. Sundquist and J. Sundquist and A.
                      Försti$^*$ and O. Hemminki and K. Hemminki$^*$},
      title        = {{B}ladder and upper urinary tract cancers as first and
                      second primary cancers.},
      journal      = {Cancer reports},
      volume       = {4},
      number       = {6},
      issn         = {2573-8348},
      address      = {Medford, MA},
      publisher    = {Wiley},
      reportid     = {DKFZ-2021-01297},
      pages        = {e1406},
      year         = {2021},
      note         = {#EA:C020# / 2021 Dec;4(6):e1406},
      abstract     = {Previous population-based studies on second primary cancers
                      (SPCs) in urothelial cancers have focused on known risk
                      factors in bladder cancer patients without data on other
                      urothelial sites of the renal pelvis or ureter.To estimate
                      sex-specific risks for any SPCs after urothelial cancers,
                      and in reverse order, for urothelial cancers as SPCs after
                      any cancer. Such two-way analysis may help interpret the
                      results.We employed standardized incidence ratios (SIRs) to
                      estimate bidirectional relative risks of subsequent cancer
                      associated with urothelial cancers. Patient data were
                      obtained from the Swedish Cancer Registry from years 1990
                      through 2015.We identified 46 234 urinary bladder cancers
                      $(75\%$ male), 940 ureteral cancers $(60\%$ male), and 2410
                      renal pelvic cancers $(57\%$ male). After male bladder
                      cancer, SIRs significantly increased for 9 SPCs, most for
                      ureteral (SIR 41.9) and renal pelvic (17.2) cancers. In the
                      reversed order (bladder cancer as SPC), 10 individual FPCs
                      were associated with an increased risk; highest associations
                      were noted after renal pelvic (21.0) and ureteral (20.9)
                      cancers. After female bladder cancer, SIRs of four SPCs were
                      significantly increased, most for ureteral (87.8) and pelvic
                      (35.7) cancers. Female bladder, ureteral, and pelvic cancers
                      associated are with endometrial cancer.The risks of
                      recurrent urothelial cancers were very high, and, at most
                      sites, female risks were twice over the male risks. Risks
                      persisted often to follow-up periods of >5 years, motivating
                      an extended patient follow-up. Lynch syndrome-related
                      cancers were associated with particularly female urothelial
                      cancers, calling for clinical vigilance.},
      keywords     = {cancer etiology (Other) / relative risk (Other) / renal
                      pelvic cancer (Other) / second primary cancer (Other) /
                      ureter cancer (Other) / urothelial cancer (Other)},
      cin          = {C050 / C020 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34114732},
      doi          = {10.1002/cnr2.1406},
      url          = {https://inrepo02.dkfz.de/record/169168},
}