001     169168
005     20240229133643.0
024 7 _ |a 10.1002/cnr2.1406
|2 doi
024 7 _ |a pmid:34114732
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037 _ _ |a DKFZ-2021-01297
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Zheng, Guoqiao
|0 P:(DE-He78)98a8f1a22ffc460364a8a34499118103
|b 0
|e First author
|u dkfz
245 _ _ |a Bladder and upper urinary tract cancers as first and second primary cancers.
260 _ _ |a Medford, MA
|c 2021
|b Wiley
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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500 _ _ |a #EA:C020# / 2021 Dec;4(6):e1406
520 _ _ |a Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter.To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as SPCs after any cancer. Such two-way analysis may help interpret the results.We employed standardized incidence ratios (SIRs) to estimate bidirectional relative risks of subsequent cancer associated with urothelial cancers. Patient data were obtained from the Swedish Cancer Registry from years 1990 through 2015.We identified 46 234 urinary bladder cancers (75% male), 940 ureteral cancers (60% male), and 2410 renal pelvic cancers (57% male). After male bladder cancer, SIRs significantly increased for 9 SPCs, most for ureteral (SIR 41.9) and renal pelvic (17.2) cancers. In the reversed order (bladder cancer as SPC), 10 individual FPCs were associated with an increased risk; highest associations were noted after renal pelvic (21.0) and ureteral (20.9) cancers. After female bladder cancer, SIRs of four SPCs were significantly increased, most for ureteral (87.8) and pelvic (35.7) cancers. Female bladder, ureteral, and pelvic cancers associated are with endometrial cancer.The risks of recurrent urothelial cancers were very high, and, at most sites, female risks were twice over the male risks. Risks persisted often to follow-up periods of >5 years, motivating an extended patient follow-up. Lynch syndrome-related cancers were associated with particularly female urothelial cancers, calling for clinical vigilance.
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650 _ 7 |a cancer etiology
|2 Other
650 _ 7 |a relative risk
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650 _ 7 |a renal pelvic cancer
|2 Other
650 _ 7 |a second primary cancer
|2 Other
650 _ 7 |a ureter cancer
|2 Other
650 _ 7 |a urothelial cancer
|2 Other
700 1 _ |a Sundquist, Kristina
|b 1
700 1 _ |a Sundquist, Jan
|b 2
700 1 _ |a Försti, Asta
|0 P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696
|b 3
|u dkfz
700 1 _ |a Hemminki, Otto
|b 4
700 1 _ |a Hemminki, Kari
|0 P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865
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773 _ _ |a 10.1002/cnr2.1406
|0 PERI:(DE-600)2920367-3
|n 6
|p e1406
|t Cancer reports
|v 4
|y 2021
|x 2573-8348
909 C O |p VDB
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910 1 _ |a Deutsches Krebsforschungszentrum
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910 1 _ |a Deutsches Krebsforschungszentrum
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914 1 _ |y 2021
915 _ _ |a DEAL Wiley
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