TY  - JOUR
AU  - Chen, Xuechen
AU  - Guo, Feng
AU  - Hoffmeister, Michael
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
TI  - Non-steroidal anti-inflammatory drugs, polygenic risk score and colorectal cancer risk.
JO  - Alimentary pharmacology & therapeutics
VL  - 54
IS  - 2
SN  - 0269-2813
CY  - Oxford
PB  - Blackwell Science
M1  - DKFZ-2021-01298
SP  - 167-175
PY  - 2021
N1  - #EA:C070#LA:C070# / 2021 Jul;54(2):167-175
AB  - The regular use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced colorectal cancer (CRC) risk.To explore whether this association varies according to background polygenic risk for CRC.Data were collected from a large population-based case-control study on CRC in Germany. A polygenic risk score (PRS) based on 140 CRC-related risk loci was used to quantify the genetic risk. The associations of regular use of NSAIDs (≥2times per week for at least 1 year) with CRC risk were estimated in the whole population and in subgroups according to PRS levels using multivariable logistic regression. The impact of NSAIDs on CRC risk was compared to PRS using the 'genetic risk equivalent' (GRE), a recently developed metric for effective risk communication.In total 5129 CRC cases and 4093 controls were included in this analysis. The regular use of NSAIDs (including aspirin) was associated with reduced CRC risk [odds ratio (OR) 0.66, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:34114659
DO  - DOI:10.1111/apt.16438
UR  - https://inrepo02.dkfz.de/record/169169
ER  -