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@ARTICLE{Wu:169184,
      author       = {J. Wu and E. Engdahl and R. Gustafsson and A. Fogdell-Hahn
                      and T. Waterboer$^*$ and J. Hillert and T. Olsson and L.
                      Alfredsson and A. K. Hedström},
      title        = {{H}igh antibody levels against human herpesvirus-6{A}
                      interact with lifestyle factors in multiple sclerosis
                      development.},
      journal      = {Multiple sclerosis journal},
      volume       = {28},
      number       = {3},
      issn         = {1477-0970},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DKFZ-2021-01308},
      pages        = {383-392},
      year         = {2022},
      note         = {2022 Mar;28(3):383-392},
      abstract     = {Infection with human herpesvirus 6A (HHV-6A) has been
                      suggested to increase multiple sclerosis (MS) risk. However,
                      potential interactions between HHV-6A and
                      environmental/lifestyle risk factors for MS have not
                      previously been studied.We used two Swedish population-based
                      case-control studies comprising 5993 cases and 5995
                      controls. Using logistic regression models, subjects with
                      different HHV-6A antibody levels, environmental exposures,
                      and lifestyle habits were compared regarding MS risk, by
                      calculating odds ratios (ORs) with $95\%$ confidence
                      intervals (CIs). Potential interactions between high HHV-6A
                      antibody levels and common environmental exposures and
                      lifestyle factors were evaluated on the additive scale.High
                      HHV-6A antibody levels were associated with increased risk
                      of developing MS (OR = 1.5, $95\%$ CI = 1.4-1.6). Regarding
                      MS risk, significant interactions were observed between high
                      HHV-6A antibody levels and both smoking (attributable
                      proportion (AP) = 0.2, $95\%$ CI = 0.1-0.3), low ultraviolet
                      radiation (UVR) exposure (AP = 0.3, $95\%$ CI = 0.1-0.4),
                      and low vitamin D levels (AP = 0.3, $95\%$ CI =
                      0.0-0.6).High HHV-6A antibody levels are associated with
                      increased MS risk and act synergistically with common
                      environmental/lifestyle risk factors for MS. Further
                      research is needed to investigate potential mechanisms
                      underlying the interactions presented in this study.},
      keywords     = {Multiple sclerosis (Other) / environmental risk factors
                      (Other) / human herpesvirus 6A (Other) / interaction
                      (Other)},
      cin          = {F022 / F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34124961},
      doi          = {10.1177/13524585211022011},
      url          = {https://inrepo02.dkfz.de/record/169184},
}