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@ARTICLE{Li:169194,
      author       = {X. Li and K. Sundquist and J. Sundquist and A. Försti$^*$
                      and K. Hemminki$^*$},
      title        = {{F}amily history of early onset acute lymphoblastic
                      leukemia is suggesting genetic associations.},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2021-01318},
      pages        = {12370},
      year         = {2021},
      abstract     = {Childhood acute lymphoblastic leukemia (ALL) has an origin
                      in the fetal period which may distinguish it from ALL
                      diagnosed later in life. We wanted to test whether familial
                      risks differ in ALL diagnosed in the very early childhood
                      from ALL diagnosed later. The Swedish nation-wide
                      family-cancer data were used until year 2016 to calculate
                      standardized incidence ratios (SIRs) for familial risks in
                      ALL in three diagnostic age-groups: 0-4, 5-34 and 35 +
                      years. Among 1335 ALL patients diagnosed before age 5,
                      familial risks were increased for esophageal (4.78), breast
                      (1.42), prostate (1.40) and connective tissue (2.97) cancers
                      and leukemia (2.51, ALL 7.81). In age-group 5-34 years,
                      rectal (1.73) and endometrial (2.40) cancer, myeloma (2.25)
                      and leukemia (2.00, ALL 4.60) reached statistical
                      significance. In the oldest age-group, the only association
                      was with Hodgkin lymphoma (3.42). Diagnostic ages of family
                      members of ALL patients were significantly lower compared to
                      these cancers in the population for breast, prostate and
                      rectal cancers. The patterns of increased familial cancers
                      suggest that BRCA2 mutations could contribute to
                      associations of ALL with breast and prostate cancers, and
                      mismatch gene PMS2 mutations with rectal and endometrial
                      cancers. Future DNA sequencing data will be a test for these
                      familial predictions.},
      cin          = {B062 / HD01},
      ddc          = {600},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34117277},
      pmc          = {pmc:PMC8195979},
      doi          = {10.1038/s41598-021-90542-7},
      url          = {https://inrepo02.dkfz.de/record/169194},
}