%0 Journal Article
%A Chen, Li-Ju
%A Trares, Kira
%A Laetsch, Dana Clarissa
%A Nguyen, Thi Ngoc Mai
%A Brenner, Hermann
%A Schöttker, Ben
%T Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication With Adverse Outcomes in Older Cancer Patients.
%J The journals of gerontology / A
%V 76
%N 6
%@ 1758-535X
%C Oxford [u.a.]
%I Oxford Univ. Pr.
%M DKFZ-2021-01386
%P 1044 - 1052
%D 2021
%Z C070#LA:C070#
%X Both polypharmacy and potentially inappropriate medication (PIM) intake are highly prevailing in older cancer patients. However, only studies on the association of polypharmacy and postoperative complications have been meta-analyzed previously.A systematic review and a meta-analysis of prospective/retrospective observational studies reporting associations of polypharmacy or PIM with at least one out of five predefined adverse health outcomes in a population of older cancer patients (≥60 years) were carried out. PubMed and Web of Science were used to search for relevant studies published between January 1991 and March 2020. Data were pooled by adopting a random-effects model.Overall, 42 publications were included in the systematic review. Meta-analyses could be performed on 39 studies about polypharmacy and 13 studies about PIM. Polypharmacy was found to be statistically significantly associated with all-cause mortality (risk ratio [95
%K Adverse drug reaction (Other)
%K Geriatric oncology (Other)
%K Hospitalizations (Other)
%K Mortality (Other)
%K Postoperative complications (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32459845
%R 10.1093/gerona/glaa128
%U https://inrepo02.dkfz.de/record/169289