TY  - JOUR
AU  - Chen, Li-Ju
AU  - Trares, Kira
AU  - Laetsch, Dana Clarissa
AU  - Nguyen, Thi Ngoc Mai
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication With Adverse Outcomes in Older Cancer Patients.
JO  - The journals of gerontology / A
VL  - 76
IS  - 6
SN  - 1758-535X
CY  - Oxford [u.a.]
PB  - Oxford Univ. Pr.
M1  - DKFZ-2021-01386
SP  - 1044 - 1052
PY  - 2021
N1  - C070#LA:C070#
AB  - Both polypharmacy and potentially inappropriate medication (PIM) intake are highly prevailing in older cancer patients. However, only studies on the association of polypharmacy and postoperative complications have been meta-analyzed previously.A systematic review and a meta-analysis of prospective/retrospective observational studies reporting associations of polypharmacy or PIM with at least one out of five predefined adverse health outcomes in a population of older cancer patients (≥60 years) were carried out. PubMed and Web of Science were used to search for relevant studies published between January 1991 and March 2020. Data were pooled by adopting a random-effects model.Overall, 42 publications were included in the systematic review. Meta-analyses could be performed on 39 studies about polypharmacy and 13 studies about PIM. Polypharmacy was found to be statistically significantly associated with all-cause mortality (risk ratio [95
KW  - Adverse drug reaction (Other)
KW  - Geriatric oncology (Other)
KW  - Hospitalizations (Other)
KW  - Mortality (Other)
KW  - Postoperative complications (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:32459845
DO  - DOI:10.1093/gerona/glaa128
UR  - https://inrepo02.dkfz.de/record/169289
ER  -