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@ARTICLE{Chen:169289,
      author       = {L.-J. Chen$^*$ and K. Trares$^*$ and D. C. Laetsch$^*$ and
                      T. N. M. Nguyen$^*$ and H. Brenner$^*$ and B.
                      Schöttker$^*$},
      title        = {{S}ystematic {R}eview and {M}eta-{A}nalysis on the
                      {A}ssociations of {P}olypharmacy and {P}otentially
                      {I}nappropriate {M}edication {W}ith {A}dverse {O}utcomes in
                      {O}lder {C}ancer {P}atients.},
      journal      = {The journals of gerontology / A},
      volume       = {76},
      number       = {6},
      issn         = {1758-535X},
      address      = {Oxford [u.a.]},
      publisher    = {Oxford Univ. Pr.},
      reportid     = {DKFZ-2021-01386},
      pages        = {1044 - 1052},
      year         = {2021},
      note         = {C070#LA:C070#},
      abstract     = {Both polypharmacy and potentially inappropriate medication
                      (PIM) intake are highly prevailing in older cancer patients.
                      However, only studies on the association of polypharmacy and
                      postoperative complications have been meta-analyzed
                      previously.A systematic review and a meta-analysis of
                      prospective/retrospective observational studies reporting
                      associations of polypharmacy or PIM with at least one out of
                      five predefined adverse health outcomes in a population of
                      older cancer patients (≥60 years) were carried out. PubMed
                      and Web of Science were used to search for relevant studies
                      published between January 1991 and March 2020. Data were
                      pooled by adopting a random-effects model.Overall, 42
                      publications were included in the systematic review.
                      Meta-analyses could be performed on 39 studies about
                      polypharmacy and 13 studies about PIM. Polypharmacy was
                      found to be statistically significantly associated with
                      all-cause mortality (risk ratio $[95\%$ confidence
                      interval]: 1.37 [1.25-1.50]), hospitalization (1.53
                      [1.37-1.71]), treatment-related toxicity (1.22 [1.01-1.47]),
                      and postoperative complications (1.73 [1.36-2.20]). The
                      association of polypharmacy with prolongation of
                      hospitalization was not statistically significant at the p <
                      .05 significance level (1.62 [0.98-2.66]). With respect to
                      PIM, a statistically significant association with all-cause
                      mortality (1.43 [1.08-1.88]) was observed but not with other
                      adverse outcomes.Polypharmacy was found to be associated
                      with several adverse outcomes and PIM use with all-cause
                      mortality in older cancer patients. However, these results
                      should be interpreted with caution because about
                      three-quarters of the studies identified did not adjust for
                      comorbidity and are prone to confounding by indication.},
      subtyp        = {Review Article},
      keywords     = {Adverse drug reaction (Other) / Geriatric oncology (Other)
                      / Hospitalizations (Other) / Mortality (Other) /
                      Postoperative complications (Other)},
      cin          = {C070},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32459845},
      doi          = {10.1093/gerona/glaa128},
      url          = {https://inrepo02.dkfz.de/record/169289},
}