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| Home > Publications database > Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication With Adverse Outcomes in Older Cancer Patients. > print |
| 001 | 169289 | ||
| 005 | 20240229133647.0 | ||
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| 100 | 1 | _ | |a Chen, Li-Ju |0 P:(DE-He78)ad44271ecf6b1eec3e0d0089c66dfdbe |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication With Adverse Outcomes in Older Cancer Patients. |
| 260 | _ | _ | |a Oxford [u.a.] |c 2021 |b Oxford Univ. Pr. |
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| 520 | _ | _ | |a Both polypharmacy and potentially inappropriate medication (PIM) intake are highly prevailing in older cancer patients. However, only studies on the association of polypharmacy and postoperative complications have been meta-analyzed previously.A systematic review and a meta-analysis of prospective/retrospective observational studies reporting associations of polypharmacy or PIM with at least one out of five predefined adverse health outcomes in a population of older cancer patients (≥60 years) were carried out. PubMed and Web of Science were used to search for relevant studies published between January 1991 and March 2020. Data were pooled by adopting a random-effects model.Overall, 42 publications were included in the systematic review. Meta-analyses could be performed on 39 studies about polypharmacy and 13 studies about PIM. Polypharmacy was found to be statistically significantly associated with all-cause mortality (risk ratio [95% confidence interval]: 1.37 [1.25-1.50]), hospitalization (1.53 [1.37-1.71]), treatment-related toxicity (1.22 [1.01-1.47]), and postoperative complications (1.73 [1.36-2.20]). The association of polypharmacy with prolongation of hospitalization was not statistically significant at the p < .05 significance level (1.62 [0.98-2.66]). With respect to PIM, a statistically significant association with all-cause mortality (1.43 [1.08-1.88]) was observed but not with other adverse outcomes.Polypharmacy was found to be associated with several adverse outcomes and PIM use with all-cause mortality in older cancer patients. However, these results should be interpreted with caution because about three-quarters of the studies identified did not adjust for comorbidity and are prone to confounding by indication. |
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| 650 | _ | 7 | |a Adverse drug reaction |2 Other |
| 650 | _ | 7 | |a Geriatric oncology |2 Other |
| 650 | _ | 7 | |a Hospitalizations |2 Other |
| 650 | _ | 7 | |a Mortality |2 Other |
| 650 | _ | 7 | |a Postoperative complications |2 Other |
| 700 | 1 | _ | |a Trares, Kira |0 P:(DE-He78)b09508a4c4afe85c57dd131eefa689ea |b 1 |u dkfz |
| 700 | 1 | _ | |a Laetsch, Dana Clarissa |0 P:(DE-He78)358cd16fe1dd16be6e4eaf0e76e5ad57 |b 2 |u dkfz |
| 700 | 1 | _ | |a Nguyen, Thi Ngoc Mai |0 P:(DE-He78)abb10265fc5b7b424eee557e979d490f |b 3 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 4 |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 5 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1093/gerona/glaa128 |g Vol. 76, no. 6, p. 1044 - 1052 |0 PERI:(DE-600)2043927-1 |n 6 |p 1044 - 1052 |t The journals of gerontology / A |v 76 |y 2021 |x 1758-535X |
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