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000169296 1001_ $$0P:(DE-He78)b542df279437ced507cda1a8c93a2d4d$$aZhang, Kevin Sun$$b0$$eFirst author$$udkfz
000169296 245__ $$aImprovement of PI-RADS-dependent prostate cancer classification by quantitative image assessment using radiomics or mean ADC.
000169296 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000169296 500__ $$a#EA:E010#LA:E010# /  2021 Jun 18;82:9-17
000169296 520__ $$aBackground Currently, interpretation of prostate MRI is performed qualitatively. Quantitative assessment of the mean apparent diffusion coefficient (mADC) is promising to improve diagnostic accuracy while radiomic machine learning (RML) allows to probe complex parameter spaces to identify the most promising multi-parametric models. We have previously developed quantitative RML and ADC classifiers for prediction of clinically significant prostate cancer (sPC) from prostate MRI, however these have not been combined with radiologist PI-RADS assessment. Purpose To propose and evaluate diagnostic algorithms combining quantitative ADC or RML and qualitative PI-RADS assessment for prediction of sPC. Methods and population The previously published quantitative models (RML and mADC) were utilized to construct four algorithms: 1) Down(ADC) and 2) Down(RML): clinically detected PI-RADS positive prostate lesions (defined as either PI-RADS≥3 or ≥4) were downgraded to MRI negative upon negative quantitative assessment; and 3) Up(ADC) and 4) Up(RML): MRI-negative lesions were upgraded to MRI-positive upon positive assessment of quantitative parameters. Analyses were performed at the individual lesion level and the patient level in 133 consecutive patients with suspicion for clinically significant prostate cancer (sPC, International Society of Urological Pathology (ISUP) grade group≥2), the test set subcohort of a previously published patient population. McNemar test was used to compare differences in sensitivity, specificity and accuracy. Differences between lesions of different prostate zones were assessed using ANOVA. Reduction in false positive assessments was assessed as ratios. Results Compared to clinical assessment at the PI-RADS≥4 cut-off alone, algorithms Down(ADC/RML) improved specificity from 43% to 65% (p = 0.001)/62% (p = 0.003), while sensitivity did not change significantly at 89% compared to 87% (p = 1.0)/89% (unchanged) on the patient level. Reduction of false positive lesions was 50% [26/52] in the PZ and 53% [15/28] in the TZ. Algorithms Up(ADC/RML) led, on a patient basis, to an unfavorable loss of specificity from 43% to 30% (p = 0.039)/32% (p = 0.106), with insignificant increase of sensitivity from 89% to 96%/96% (both p = 1.0). Compared to clinical assessment at the PI-RADS≥3 cut-off alone, similar results were observed for Down(ADC) with significantly increased specificity from 2% to 23% (p < 0.001) and unchanged sensitivity on the lesion level; patient level specificity increased only non-significantly. Conclusion Downgrading PI-RADS≥3 and ≥ 4 lesions based on quantitative mADC measurements or RML classifiers can increase diagnostic accuracy by enhancing specificity and preserving sensitivity for detection of sPC and reduce false positives.
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000169296 650_7 $$2Other$$aADC
000169296 650_7 $$2Other$$aMRI
000169296 650_7 $$2Other$$aPI-RADS
000169296 650_7 $$2Other$$aProstate cancer
000169296 650_7 $$2Other$$aRadiomics
000169296 7001_ $$0P:(DE-He78)4b5e5faa688c6b833c70b6777f91f662$$aSchelb, Patrick$$b1$$udkfz
000169296 7001_ $$0P:(DE-He78)a35f3fa04c359e037b2377f96920f93f$$aKohl, Simon$$b2
000169296 7001_ $$0P:(DE-He78)79897f8897ff77676549d9895258a0f2$$aRadtke, Jan Philipp$$b3$$udkfz
000169296 7001_ $$0P:(DE-He78)1042737c83ba70ec508bdd99f0096864$$aWiesenfarth, Manuel$$b4$$udkfz
000169296 7001_ $$aSchimmöller, Lars$$b5
000169296 7001_ $$0P:(DE-He78)59dfdd0ee0a7f0db81535f0781a3a6d6$$aKuder, Tristan Anselm$$b6$$udkfz
000169296 7001_ $$aStenzinger, Albrecht$$b7
000169296 7001_ $$aHohenfellner, Markus$$b8
000169296 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b9$$udkfz
000169296 7001_ $$0P:(DE-He78)33c74005e1ce56f7025c4f6be15321b3$$aMaier-Hein, Klaus$$b10$$udkfz
000169296 7001_ $$0P:(DE-He78)ea098e4d78abeb63afaf8c25ec6d6d93$$aBonekamp, David$$b11$$eLast author$$udkfz
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