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@ARTICLE{Kommoss:169348,
      author       = {F. K. Kommoss$^*$ and C. Kölsche$^*$ and T. Mentzel and D.
                      Schmidt and A. von Deimling$^*$ and W. G. McCluggage and F.
                      Kommoss},
      title        = {{S}pindle {C}ell {S}arcoma of the {U}terine {C}orpus {W}ith
                      {A}dipose {M}etaplasia: {E}xpanding the {M}orphologic
                      {S}pectrum of {N}eoplasms {W}ith {MEIS}1-{NCOA}2 {G}ene
                      {F}usion.},
      journal      = {International journal of gynecological pathology},
      volume       = {41},
      number       = {4},
      issn         = {0277-1691},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DKFZ-2021-01428},
      pages        = {417-422},
      year         = {2022},
      note         = {2022 Jul 1;41(4):417-422},
      abstract     = {We report a spindle cell sarcoma arising in the uterine
                      corpus of a 26-yr-old patient. The patient underwent a
                      simple hysterectomy and the uterine corpus contained a 9 cm
                      tumor showing nodular and 'finger-like' myometrial invasion.
                      Histologically, the tumor was composed of a monomorphic
                      population of atypical spindle cells which contained
                      widespread foci of cytologically benign adipocytes.
                      Immunohistochemistry revealed diffuse strong positivity for
                      CD10, CD56, and CD99 and diffuse weak positive staining with
                      ER and WT1 while smooth muscle markers, S100, TLE1, and
                      cyclin D1 were negative. Total RNA sequencing identified an
                      in-frame fusion between exon 6 of MEIS1 and exon 12 of
                      NCOA2. Copy number analysis revealed few aberrations with no
                      deletions or amplifications identified. No adjuvant therapy
                      was given and the patient is disease-free 9 yr after initial
                      diagnosis. This case represents the second report of a
                      uterine sarcoma harboring a MEIS1-NCOA2/1 gene fusion and
                      expands the morphologic spectrum of recently reported
                      spindle cell sarcomas arising in the genitourinary tract
                      harboring MEIS1-NCOA2/1 gene fusions. This is the first
                      reported case of such tumors with an adipocytic component.},
      cin          = {HD01 / B300},
      ddc          = {610},
      cid          = {I:(DE-He78)HD01-20160331 / I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34166279},
      doi          = {10.1097/PGP.0000000000000803},
      url          = {https://inrepo02.dkfz.de/record/169348},
}