%0 Journal Article
%A Ballabio, Claudio
%A Gianesello, Matteo
%A Lago, Chiara
%A Okonechnikov, Konstantin
%A Anderle, Marica
%A Aiello, Giuseppe
%A Antonica, Francesco
%A Zhang, Tingting
%A Gianno, Francesca
%A Giangaspero, Felice
%A Hassan, Bassem A
%A Pfister, Stefan
%A Tiberi, Luca
%T Notch1 switches progenitor competence in inducing medulloblastoma.
%J Science advances
%V 7
%N 26
%@ 2375-2548
%C Washington, DC [u.a.]
%I Assoc.
%M DKFZ-2021-01432
%P eabd2781 -
%D 2021
%X The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate group 3 MB, and we observed that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. We found that additional activation of Notch1 in Math1+ and Sox2+ cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34162555
%R 10.1126/sciadv.abd2781
%U https://inrepo02.dkfz.de/record/169352