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000169352 1001_ $$00000-0001-6632-1489$$aBallabio, Claudio$$b0
000169352 245__ $$aNotch1 switches progenitor competence in inducing medulloblastoma.
000169352 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2021
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000169352 520__ $$aThe identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate group 3 MB, and we observed that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. We found that additional activation of Notch1 in Math1+ and Sox2+ cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation.
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000169352 7001_ $$00000-0002-8976-6883$$aGianesello, Matteo$$b1
000169352 7001_ $$00000-0002-1317-7847$$aLago, Chiara$$b2
000169352 7001_ $$0P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aOkonechnikov, Konstantin$$b3$$udkfz
000169352 7001_ $$00000-0002-6840-551X$$aAnderle, Marica$$b4
000169352 7001_ $$00000-0001-8723-2127$$aAiello, Giuseppe$$b5
000169352 7001_ $$00000-0001-9359-9689$$aAntonica, Francesco$$b6
000169352 7001_ $$aZhang, Tingting$$b7
000169352 7001_ $$00000-0002-6223-9952$$aGianno, Francesca$$b8
000169352 7001_ $$00000-0001-5382-2380$$aGiangaspero, Felice$$b9
000169352 7001_ $$00000-0001-9533-4908$$aHassan, Bassem A$$b10
000169352 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b11$$udkfz
000169352 7001_ $$00000-0002-5983-3782$$aTiberi, Luca$$b12
000169352 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.abd2781$$gVol. 7, no. 26, p. eabd2781 -$$n26$$peabd2781 -$$tScience advances$$v7$$x2375-2548$$y2021
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