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@ARTICLE{Ballabio:169352,
      author       = {C. Ballabio and M. Gianesello and C. Lago and K.
                      Okonechnikov$^*$ and M. Anderle and G. Aiello and F.
                      Antonica and T. Zhang and F. Gianno and F. Giangaspero and
                      B. A. Hassan and S. Pfister$^*$ and L. Tiberi},
      title        = {{N}otch1 switches progenitor competence in inducing
                      medulloblastoma.},
      journal      = {Science advances},
      volume       = {7},
      number       = {26},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2021-01432},
      pages        = {eabd2781 -},
      year         = {2021},
      abstract     = {The identity of the cell of origin is a key determinant of
                      cancer subtype, progression, and prognosis. Group 3
                      medulloblastoma (MB) is a malignant childhood brain cancer
                      with poor prognosis and few candidates as putative cell of
                      origin. We overexpressed the group 3 MB genetic drivers MYC
                      and Gfi1 in different candidate cells of origin in the
                      postnatal mouse cerebellum. We found that S100b+ cells are
                      competent to initiate group 3 MB, and we observed that
                      S100b+ cells have higher levels of Notch1 pathway activity
                      compared to Math1+ cells. We found that additional
                      activation of Notch1 in Math1+ and Sox2+ cells was
                      sufficient to induce group 3 MB upon MYC/Gfi1 expression.
                      Together, our data suggest that the Notch1 pathway plays a
                      critical role in group 3 MB initiation.},
      cin          = {B062 / HD01},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34162555},
      doi          = {10.1126/sciadv.abd2781},
      url          = {https://inrepo02.dkfz.de/record/169352},
}