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100 1 _ |a Ballabio, Claudio
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245 _ _ |a Notch1 switches progenitor competence in inducing medulloblastoma.
260 _ _ |a Washington, DC [u.a.]
|c 2021
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520 _ _ |a The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate group 3 MB, and we observed that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. We found that additional activation of Notch1 in Math1+ and Sox2+ cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation.
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700 1 _ |a Gianesello, Matteo
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700 1 _ |a Lago, Chiara
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700 1 _ |a Okonechnikov, Konstantin
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700 1 _ |a Anderle, Marica
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700 1 _ |a Aiello, Giuseppe
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700 1 _ |a Antonica, Francesco
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700 1 _ |a Zhang, Tingting
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700 1 _ |a Gianno, Francesca
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700 1 _ |a Giangaspero, Felice
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700 1 _ |a Hassan, Bassem A
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700 1 _ |a Pfister, Stefan
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700 1 _ |a Tiberi, Luca
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773 _ _ |a 10.1126/sciadv.abd2781
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