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000169353 1001_ $$00000-0003-0937-5290$$aYoung, Matthew D$$b0
000169353 245__ $$aSingle cell derived mRNA signals across human kidney tumors.
000169353 260__ $$a[London]$$bNature Publishing Group UK$$c2021
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000169353 520__ $$aTumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference 'cellular signals' in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of 'fetalness' with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer.
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000169353 7001_ $$00000-0003-0761-9503$$aMitchell, Thomas J$$b1
000169353 7001_ $$00000-0003-0252-7714$$aCusters, Lars$$b2
000169353 7001_ $$aMargaritis, Thanasis$$b3
000169353 7001_ $$aMorales-Rodriguez, Francisco$$b4
000169353 7001_ $$aKwakwa, Kwasi$$b5
000169353 7001_ $$00000-0002-5891-6789$$aKhabirova, Eleonora$$b6
000169353 7001_ $$00000-0002-5314-2294$$aKildisiute, Gerda$$b7
000169353 7001_ $$00000-0003-4306-0102$$aOliver, Thomas R W$$b8
000169353 7001_ $$ade Krijger, Ronald R$$b9
000169353 7001_ $$00000-0002-7760-879X$$avan den Heuvel-Eibrink, Marry M$$b10
000169353 7001_ $$00000-0003-3226-1179$$aComitani, Federico$$b11
000169353 7001_ $$00000-0001-8251-3309$$aPiapi, Alice$$b12
000169353 7001_ $$aBugallo-Blanco, Eva$$b13
000169353 7001_ $$aThevanesan, Christine$$b14
000169353 7001_ $$00000-0001-5381-3185$$aBurke, Christina$$b15
000169353 7001_ $$aPrigmore, Elena$$b16
000169353 7001_ $$aAmbridge, Kirsty$$b17
000169353 7001_ $$00000-0001-6155-0821$$aRoberts, Kenny$$b18
000169353 7001_ $$aBraga, Felipe A Vieira$$b19
000169353 7001_ $$00000-0002-5826-3554$$aCoorens, Tim H H$$b20
000169353 7001_ $$aDel Valle, Ignacio$$b21
000169353 7001_ $$aWilbrey-Clark, Anna$$b22
000169353 7001_ $$00000-0003-1463-8622$$aMamanova, Lira$$b23
000169353 7001_ $$00000-0003-3188-9140$$aStewart, Grant D$$b24
000169353 7001_ $$aGnanapragasam, Vincent J$$b25
000169353 7001_ $$aRampling, Dyanne$$b26
000169353 7001_ $$aSebire, Neil$$b27
000169353 7001_ $$aColeman, Nicholas$$b28
000169353 7001_ $$aHook, Liz$$b29
000169353 7001_ $$00000-0002-1170-7867$$aWarren, Anne$$b30
000169353 7001_ $$00000-0002-3927-2084$$aHaniffa, Muzlifah$$b31
000169353 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b32$$udkfz
000169353 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b33$$udkfz
000169353 7001_ $$00000-0001-8787-6272$$aAchermann, John C$$b34
000169353 7001_ $$aHe, Xiaoling$$b35
000169353 7001_ $$aBarker, Roger A$$b36
000169353 7001_ $$aShlien, Adam$$b37
000169353 7001_ $$00000-0001-6055-277X$$aBayraktar, Omer A$$b38
000169353 7001_ $$00000-0002-6294-6366$$aTeichmann, Sarah A$$b39
000169353 7001_ $$00000-0002-8090-5146$$aHolstege, Frank C$$b40
000169353 7001_ $$00000-0001-5906-1498$$aMeyer, Kerstin B$$b41
000169353 7001_ $$00000-0002-2941-6179$$aDrost, Jarno$$b42
000169353 7001_ $$00000-0001-9673-8568$$aStraathof, Karin$$b43
000169353 7001_ $$00000-0002-6600-7665$$aBehjati, Sam$$b44
000169353 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-021-23949-5$$gVol. 12, no. 1, p. 3896$$n1$$p3896$$tNature Communications$$v12$$x2041-1723$$y2021
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