TY  - JOUR
AU  - Young, Matthew D
AU  - Mitchell, Thomas J
AU  - Custers, Lars
AU  - Margaritis, Thanasis
AU  - Morales-Rodriguez, Francisco
AU  - Kwakwa, Kwasi
AU  - Khabirova, Eleonora
AU  - Kildisiute, Gerda
AU  - Oliver, Thomas R W
AU  - de Krijger, Ronald R
AU  - van den Heuvel-Eibrink, Marry M
AU  - Comitani, Federico
AU  - Piapi, Alice
AU  - Bugallo-Blanco, Eva
AU  - Thevanesan, Christine
AU  - Burke, Christina
AU  - Prigmore, Elena
AU  - Ambridge, Kirsty
AU  - Roberts, Kenny
AU  - Braga, Felipe A Vieira
AU  - Coorens, Tim H H
AU  - Del Valle, Ignacio
AU  - Wilbrey-Clark, Anna
AU  - Mamanova, Lira
AU  - Stewart, Grant D
AU  - Gnanapragasam, Vincent J
AU  - Rampling, Dyanne
AU  - Sebire, Neil
AU  - Coleman, Nicholas
AU  - Hook, Liz
AU  - Warren, Anne
AU  - Haniffa, Muzlifah
AU  - Kool, Marcel
AU  - Pfister, Stefan M
AU  - Achermann, John C
AU  - He, Xiaoling
AU  - Barker, Roger A
AU  - Shlien, Adam
AU  - Bayraktar, Omer A
AU  - Teichmann, Sarah A
AU  - Holstege, Frank C
AU  - Meyer, Kerstin B
AU  - Drost, Jarno
AU  - Straathof, Karin
AU  - Behjati, Sam
TI  - Single cell derived mRNA signals across human kidney tumors.
JO  - Nature Communications
VL  - 12
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2021-01433
SP  - 3896
PY  - 2021
AB  - Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference 'cellular signals' in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of 'fetalness' with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer.
LB  - PUB:(DE-HGF)16
C6  - pmid:34162837
DO  - DOI:10.1038/s41467-021-23949-5
UR  - https://inrepo02.dkfz.de/record/169353
ER  -