000169377 001__ 169377
000169377 005__ 20240229133649.0
000169377 0247_ $$2doi$$a10.1038/s41598-021-90381-6
000169377 0247_ $$2pmid$$apmid:34035403
000169377 0247_ $$2pmc$$apmc:PMC8149814
000169377 037__ $$aDKFZ-2021-01456
000169377 041__ $$aEnglish
000169377 082__ $$a600
000169377 1001_ $$aPorubsky, Stefan$$b0
000169377 245__ $$aThe prognostic value of galactosylceramide-sulfotransferase (Gal3ST1) in human renal cell carcinoma.
000169377 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2021
000169377 3367_ $$2DRIVER$$aarticle
000169377 3367_ $$2DataCite$$aOutput Types/Journal article
000169377 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1630392827_30127
000169377 3367_ $$2BibTeX$$aARTICLE
000169377 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000169377 3367_ $$00$$2EndNote$$aJournal Article
000169377 520__ $$aRenal cell carcinoma (RCC) is the deadliest primary genitourinary malignancy typically associated with asymptomatic initial presentation and poorly predictable survival. Next to established risk factors, tumor microenvironment may alter metastatic capacity and immune landscape. Due to their high concentrations, sulfoglycolipids (sulfatides) were among the first well-described antigens in RCC that are associated with worse prognosis. As sulfatide detection in routine diagnostics is not possible, we aimed to test the prognostic value of its protein counterpart, sulfatide-producing enzyme Gal3ST1. We performed retrospective long-term follow up analysis of Gal3ST1 expression as prognostic risk factor in a representative RCC patient cohort. We observed differentially regulated Gal3ST1 expression in all RCC types, being significantly more associated with clear cell RCC than to chromophobe RCC (p = 0.001). Surprisingly, in contrast to published observations from in vitro models, we could not confirm an association between Gal3ST1 expression and a malignant clinical behaviour of the RCC. In our cohort, Gal3ST1 did not significantly influence progression-free survival (Hazard Ratio (HR): 1.7 95% CI (0.6-4.9), p = 0.327). Particularly after adjusting for histology, T-stage, N-status and M-status at baseline, we observed no independent prognostic effect (HR = 1.0 95% CI (0.3-3.3), p = 0.96). The analysis of Gal3ST1 mRNA expression in a TCGA dataset supported the results of our cohort. Thus, Gal3ST1 might help to differentiate between chromophobe RCC and other frequent RCC entities but-despite previously published data from cell culture models-does not qualify as a prognostic marker for RCC. Further investigation of regulatory mechanisms of sulfatide metabolism in human RCC microenvironment is necessary to understand the role of this quantitatively prominent glycosphingolipid in RCC progression.
000169377 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000169377 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000169377 7001_ $$aNientiedt, Malin$$b1
000169377 7001_ $$aKriegmair, Maximilian C$$b2
000169377 7001_ $$aSiemoneit, Jörn-Helge Heinrich$$b3
000169377 7001_ $$0P:(DE-He78)a928ded2085c8911822370cad0b4a728$$aSandhoff, Roger$$b4$$udkfz
000169377 7001_ $$0P:(DE-He78)3caae9893e3b2704f7bb5a9646ef084d$$aJennemann, Richard$$b5$$udkfz
000169377 7001_ $$aBorgmann, Hendrik$$b6
000169377 7001_ $$aGaiser, Timo$$b7
000169377 7001_ $$aWeis, Cleo-Aron$$b8
000169377 7001_ $$aErben, Philipp$$b9
000169377 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b10
000169377 7001_ $$aPopovic, Zoran V$$b11
000169377 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-021-90381-6$$gVol. 11, no. 1, p. 10926$$n1$$p10926$$tScientific reports$$v11$$x2045-2322$$y2021
000169377 909CO $$ooai:inrepo02.dkfz.de:169377$$pVDB
000169377 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a928ded2085c8911822370cad0b4a728$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000169377 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3caae9893e3b2704f7bb5a9646ef084d$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000169377 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000169377 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000169377 9130_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000169377 9141_ $$y2021
000169377 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI REP-UK : 2019$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-02-03
000169377 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-02-03
000169377 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-02-03
000169377 9201_ $$0I:(DE-He78)C060-20160331$$kC060$$lC060 Biostatistik$$x0
000169377 9201_ $$0I:(DE-He78)A411-20160331$$kA411$$lLipid-Pathobiochemie$$x1
000169377 980__ $$ajournal
000169377 980__ $$aVDB
000169377 980__ $$aI:(DE-He78)C060-20160331
000169377 980__ $$aI:(DE-He78)A411-20160331
000169377 980__ $$aUNRESTRICTED