TY  - JOUR
AU  - Porubsky, Stefan
AU  - Nientiedt, Malin
AU  - Kriegmair, Maximilian C
AU  - Siemoneit, Jörn-Helge Heinrich
AU  - Sandhoff, Roger
AU  - Jennemann, Richard
AU  - Borgmann, Hendrik
AU  - Gaiser, Timo
AU  - Weis, Cleo-Aron
AU  - Erben, Philipp
AU  - Hielscher, Thomas
AU  - Popovic, Zoran V
TI  - The prognostic value of galactosylceramide-sulfotransferase (Gal3ST1) in human renal cell carcinoma.
JO  - Scientific reports
VL  - 11
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2021-01456
SP  - 10926
PY  - 2021
AB  - Renal cell carcinoma (RCC) is the deadliest primary genitourinary malignancy typically associated with asymptomatic initial presentation and poorly predictable survival. Next to established risk factors, tumor microenvironment may alter metastatic capacity and immune landscape. Due to their high concentrations, sulfoglycolipids (sulfatides) were among the first well-described antigens in RCC that are associated with worse prognosis. As sulfatide detection in routine diagnostics is not possible, we aimed to test the prognostic value of its protein counterpart, sulfatide-producing enzyme Gal3ST1. We performed retrospective long-term follow up analysis of Gal3ST1 expression as prognostic risk factor in a representative RCC patient cohort. We observed differentially regulated Gal3ST1 expression in all RCC types, being significantly more associated with clear cell RCC than to chromophobe RCC (p = 0.001). Surprisingly, in contrast to published observations from in vitro models, we could not confirm an association between Gal3ST1 expression and a malignant clinical behaviour of the RCC. In our cohort, Gal3ST1 did not significantly influence progression-free survival (Hazard Ratio (HR): 1.7 95
LB  - PUB:(DE-HGF)16
C6  - pmid:34035403
C2  - pmc:PMC8149814
DO  - DOI:10.1038/s41598-021-90381-6
UR  - https://inrepo02.dkfz.de/record/169377
ER  -