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@ARTICLE{Cardoso:169387,
      author       = {R. Cardoso$^*$ and A. Zhu$^*$ and F. Guo$^*$ and T.
                      Heisser$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{I}ncidence and {M}ortality of {P}roximal and {D}istal
                      {C}olorectal {C}ancer in {G}ermany.},
      journal      = {Deutsches Ärzteblatt international},
      volume       = {118},
      number       = {16},
      issn         = {1866-0452},
      address      = {Köln},
      publisher    = {Dt. Ärzte-Verl.},
      reportid     = {DKFZ-2021-01461},
      pages        = {281-287},
      year         = {2021},
      note         = {#EA:C120#LA:C070#},
      abstract     = {The use of colonoscopy has increased and colorectal cancer
                      (CRC) incidence has decreased after the introduction of
                      screening colonoscopy in Germany. However, it remains
                      unknown to what extent progress has been achieved in the
                      prevention of cancer in the proximal colon, distal colon,
                      and rectum.We analyzed trends in CRC incidence (2000-2016)
                      and mortality (2000-2018) in Germany by sex, age, and tumor
                      location.The age-standardized incidence of CRC declined by
                      $22.4\%$ (from 65.3 to 50.7 per 100 000) in men and by
                      $25.5\%$ (from 42.7 to 31.8 per 100 000) in women. CRC
                      mortality declined by $35.8\%$ (from 29.6 to 19.0 per 100
                      000) in men and by $40.5\%$ (19.0 to 11.3 per 100 000) in
                      women. Despite demographic changes, the annual numbers of
                      CRC cases and deaths still decreased from about 60 400 to 58
                      300 and from around 28 700 to 24 200, respectively. The
                      decline in incidence was greatest in groups aged ≥ 55
                      years. While the incidence of cancer in the distal colon and
                      rectum decreased by $34.5\%$ and $26.2\%,$ respectively, in
                      men and by $41.0\%$ and $27.9\%$ in women, the incidence of
                      proximal colon cancer remained stable in men and decreased
                      by only $7.0\%$ in women. However, a major shift towards
                      earlier stages was observed for the proximal cancers.The
                      results support the assumption that the increased use of
                      colo - noscopy has contributed to substantial reductions in
                      the incidence of distal CRC incidence and the mortality from
                      cancers in the entire colon and rectum.},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34180790},
      doi          = {10.3238/arztebl.m2021.0111},
      url          = {https://inrepo02.dkfz.de/record/169387},
}