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@ARTICLE{Louis:169392,
      author       = {D. N. Louis and A. Perry and P. Wesseling and D. J. Brat
                      and I. A. Cree and D. Figarella-Branger and C. Hawkins and
                      H. K. Ng and S. M. Pfister$^*$ and G. Reifenberger$^*$ and
                      R. Soffietti and A. von Deimling$^*$ and D. W. Ellison},
      title        = {{T}he 2021 {WHO} {C}lassification of {T}umors of the
                      {C}entral {N}ervous {S}ystem: a summary.},
      journal      = {Neuro-Oncology},
      volume       = {23},
      number       = {8},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2021-01466},
      pages        = {1231-1251},
      year         = {2021},
      note         = {2021 Aug 2;23(8):1231-1251},
      abstract     = {The fifth edition of the WHO Classification of Tumors of
                      the Central Nervous System (CNS), published in 2021, is the
                      sixth version of the international standard for the
                      classification of brain and spinal cord tumors. Building on
                      the 2016 updated fourth edition and the work of the
                      Consortium to Inform Molecular and Practical Approaches to
                      CNS Tumor Taxonomy, the 2021 fifth edition introduces major
                      changes that advance the role of molecular diagnostics in
                      CNS tumor classification. At the same time, it remains
                      wedded to other established approaches to tumor diagnosis
                      such as histology and immunohistochemistry. In doing so, the
                      fifth edition establishes some different approaches to both
                      CNS tumor nomenclature and grading and it emphasizes the
                      importance of integrated diagnoses and layered reports. New
                      tumor types and subtypes are introduced, some based on novel
                      diagnostic technologies such as DNA methylome profiling. The
                      present review summarizes the major general changes in the
                      2021 fifth edition classification and the specific changes
                      in each taxonomic category. It is hoped that this summary
                      provides an overview to facilitate more in-depth exploration
                      of the entire fifth edition of the WHO Classification of
                      Tumors of the Central Nervous System.},
      subtyp        = {Review Article},
      keywords     = {World Health Organization (Other) / brain tumor (Other) /
                      central nervous system (Other) / classification (Other) /
                      diagnosis (Other)},
      cin          = {B062 / HD01 / ED01 / B300},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)ED01-20160331 / I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34185076},
      doi          = {10.1093/neuonc/noab106},
      url          = {https://inrepo02.dkfz.de/record/169392},
}