000169401 001__ 169401
000169401 005__ 20240229133650.0
000169401 0247_ $$2doi$$a10.1001/jamasurg.2021.2380
000169401 0247_ $$2pmid$$apmid:34190968
000169401 0247_ $$2ISSN$$a0004-0010
000169401 0247_ $$2ISSN$$a0096-6908
000169401 0247_ $$2ISSN$$a0272-5533
000169401 0247_ $$2ISSN$$a1538-3644
000169401 0247_ $$2ISSN$$a2168-6254
000169401 0247_ $$2ISSN$$a2168-6262
000169401 0247_ $$2ISSN$$a2376-3566
000169401 0247_ $$2ISSN$$a2376-3590
000169401 0247_ $$2altmetric$$aaltmetric:108453045
000169401 037__ $$aDKFZ-2021-01475
000169401 041__ $$aEnglish
000169401 082__ $$a610
000169401 1001_ $$aREACCT Collaborative$$b0$$eCollaboration Author
000169401 245__ $$aCharacteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
000169401 260__ $$aChicago, Ill.$$bAmerican Medical Association$$c2021
000169401 3367_ $$2DRIVER$$aarticle
000169401 3367_ $$2DataCite$$aOutput Types/Journal article
000169401 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1643380961_27487$$xReview Article
000169401 3367_ $$2BibTeX$$aARTICLE
000169401 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000169401 3367_ $$00$$2EndNote$$aJournal Article
000169401 500__ $$a2021 Sep 1;156(9):865-874
000169401 520__ $$aThe incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.
000169401 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000169401 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000169401 7001_ $$aZaborowski, Alexandra M$$b1
000169401 7001_ $$aAbdile, Ahmed$$b2
000169401 7001_ $$aAdamina, Michel$$b3
000169401 7001_ $$aAigner, Felix$$b4
000169401 7001_ $$ad'Allens, Laura$$b5
000169401 7001_ $$aAllmer, Caterina$$b6
000169401 7001_ $$aÁlvarez, Andrea$$b7
000169401 7001_ $$aAnula, Rocio$$b8
000169401 7001_ $$aAndric, Mihailo$$b9
000169401 7001_ $$aAtallah, Sam$$b10
000169401 7001_ $$aBach, Simon$$b11
000169401 7001_ $$aBala, Miklosh$$b12
000169401 7001_ $$aBarussaud, Marie$$b13
000169401 7001_ $$aBausys, Augustinas$$b14
000169401 7001_ $$aBebington, Brendan$$b15
000169401 7001_ $$aBeggs, Andrew$$b16
000169401 7001_ $$aBellolio, Felipe$$b17
000169401 7001_ $$aBennett, Melissa-Rose$$b18
000169401 7001_ $$aBerdinskikh, Anton$$b19
000169401 7001_ $$aBevan, Vicki$$b20
000169401 7001_ $$aBiondo, Sebastiano$$b21
000169401 7001_ $$aBislenghi, Gabriele$$b22
000169401 7001_ $$aBludau, Marc$$b23
000169401 7001_ $$aBoutall, Adam$$b24
000169401 7001_ $$aBrouwer, Nelleke$$b25
000169401 7001_ $$aBrown, Carl$$b26
000169401 7001_ $$aBruns, Christiane$$b27
000169401 7001_ $$aBuchanan, Daniel D$$b28
000169401 7001_ $$aBuchwald, Pamela$$b29
000169401 7001_ $$aBurger, Jacobus W A$$b30
000169401 7001_ $$aBurlov, Nikita$$b31
000169401 7001_ $$aCampanelli, Michela$$b32
000169401 7001_ $$aCapdepont, Maylis$$b33
000169401 7001_ $$aCarvello, Michele$$b34
000169401 7001_ $$aChew, Hwee-Hoon$$b35
000169401 7001_ $$aChristoforidis, Dimitri$$b36
000169401 7001_ $$aClark, David$$b37
000169401 7001_ $$aCliment, Marta$$b38
000169401 7001_ $$aCologne, Kyle G$$b39
000169401 7001_ $$aContreras, Tomas$$b40
000169401 7001_ $$aCroner, Roland$$b41
000169401 7001_ $$aDaniels, Ian R$$b42
000169401 7001_ $$aDapri, Giovanni$$b43
000169401 7001_ $$aDavies, Justin$$b44
000169401 7001_ $$aDelrio, Paolo$$b45
000169401 7001_ $$aDenost, Quentin$$b46
000169401 7001_ $$aDeutsch, Michael$$b47
000169401 7001_ $$aDias, Andre$$b48
000169401 7001_ $$aD'Hoore, André$$b49
000169401 7001_ $$aDrozdov, Evgeniy$$b50
000169401 7001_ $$aDuek, Daniel$$b51
000169401 7001_ $$aDunlop, Malcolm$$b52
000169401 7001_ $$aDziki, Adam$$b53
000169401 7001_ $$aEdmundson, Aleksandra$$b54
000169401 7001_ $$aEfetov, Sergey$$b55
000169401 7001_ $$aEl-Hussuna, Alaa$$b56
000169401 7001_ $$aElliot, Brodie$$b57
000169401 7001_ $$aEmile, Sameh$$b58
000169401 7001_ $$aEspin, Eloy$$b59
000169401 7001_ $$aEvans, Martyn$$b60
000169401 7001_ $$aFaes, Seraina$$b61
000169401 7001_ $$aFaiz, Omar$$b62
000169401 7001_ $$aFleming, Fergal$$b63
000169401 7001_ $$aFoppa, Caterina$$b64
000169401 7001_ $$aFowler, George$$b65
000169401 7001_ $$aFrasson, Matteo$$b66
000169401 7001_ $$aFigueiredo, Nuno$$b67
000169401 7001_ $$aForgan, Tim$$b68
000169401 7001_ $$aFrizelle, Frank$$b69
000169401 7001_ $$aGadaev, Shamil$$b70
000169401 7001_ $$aGellona, Jose$$b71
000169401 7001_ $$aGlyn, Tamara$$b72
000169401 7001_ $$aGong, Jianping$$b73
000169401 7001_ $$aGoran, Barisic$$b74
000169401 7001_ $$aGreenwood, Emma$$b75
000169401 7001_ $$aGuren, Marianne G$$b76
000169401 7001_ $$aGuillon, Stephanie$$b77
000169401 7001_ $$aGutlic, Ida$$b78
000169401 7001_ $$aHahnloser, Dieter$$b79
000169401 7001_ $$aHampel, Heather$$b80
000169401 7001_ $$aHanly, Ann$$b81
000169401 7001_ $$aHasegawa, Hirotoshi$$b82
000169401 7001_ $$aIversen, Lene Hjerrild$$b83
000169401 7001_ $$aHill, Andrew$$b84
000169401 7001_ $$aHill, James$$b85
000169401 7001_ $$aHoch, Jiri$$b86
000169401 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b87$$udkfz
000169401 7001_ $$aHompes, Roel$$b88
000169401 7001_ $$aHurtado, Luis$$b89
000169401 7001_ $$aIaquinandi, Fabiano$$b90
000169401 7001_ $$aImbrasaite, Ugne$$b91
000169401 7001_ $$aIslam, Rumana$$b92
000169401 7001_ $$aJafari, Mehrenah Dorna$$b93
000169401 7001_ $$aKanemitsu, Yukihide$$b94
000169401 7001_ $$aKarachun, Aleksei$$b95
000169401 7001_ $$aKarimuddin, Ahmer A$$b96
000169401 7001_ $$aKeller, Deborah S$$b97
000169401 7001_ $$aKelly, Justin$$b98
000169401 7001_ $$aKennelly, Rory$$b99
000169401 7001_ $$aKhrykov, Gleb$$b100
000169401 7001_ $$aKocian, Peter$$b101
000169401 7001_ $$aKoh, Cherry$$b102
000169401 7001_ $$aKok, Neils$$b103
000169401 7001_ $$aKnight, Katrina A$$b104
000169401 7001_ $$aKnol, Joep$$b105
000169401 7001_ $$aKontovounisios, Christos$$b106
000169401 7001_ $$aKorner, Hartwig$$b107
000169401 7001_ $$aKrivokapic, Zoran$$b108
000169401 7001_ $$aKronberger, Irmgard$$b109
000169401 7001_ $$aKroon, Hidde Maarten$$b110
000169401 7001_ $$aKryzauskas, Marius$$b111
000169401 7001_ $$aKural, Said$$b112
000169401 7001_ $$aKusters, Miranda$$b113
000169401 7001_ $$aLakkis, Zaher$$b114
000169401 7001_ $$aLankov, Timur$$b115
000169401 7001_ $$aLarson, Dave$$b116
000169401 7001_ $$aLázár, György$$b117
000169401 7001_ $$aLee, Kai-Yin$$b118
000169401 7001_ $$aLee, Suk Hwan$$b119
000169401 7001_ $$aLefèvre, Jérémie H$$b120
000169401 7001_ $$aLepisto, Anna$$b121
000169401 7001_ $$aLieu, Christopher$$b122
000169401 7001_ $$aLoi, Lynette$$b123
000169401 7001_ $$aLynch, Craig$$b124
000169401 7001_ $$aMaillou-Martinaud, Helene$$b125
000169401 7001_ $$aMaroli, Annalisa$$b126
000169401 7001_ $$aMartin, Sean$$b127
000169401 7001_ $$aMartling, Anna$$b128
000169401 7001_ $$aMatzel, Klaus E$$b129
000169401 7001_ $$aMayol, Julio$$b130
000169401 7001_ $$aMcDermott, Frank$$b131
000169401 7001_ $$aMeurette, Guillaume$$b132
000169401 7001_ $$aMillan, Monica$$b133
000169401 7001_ $$aMitteregger, Martin$$b134
000169401 7001_ $$aMoiseenko, Andrei$$b135
000169401 7001_ $$aMonson, John R T$$b136
000169401 7001_ $$aMorarasu, Stefan$$b137
000169401 7001_ $$aMoritani, Konosuke$$b138
000169401 7001_ $$aMöslein, Gabriela$$b139
000169401 7001_ $$aMunini, Martino$$b140
000169401 7001_ $$aNahas, Caio$$b141
000169401 7001_ $$aNahas, Sergio$$b142
000169401 7001_ $$aNegoi, Ionut$$b143
000169401 7001_ $$aNovikova, Anastasia$$b144
000169401 7001_ $$aOcares, Misael$$b145
000169401 7001_ $$aOkabayashi, Koji$$b146
000169401 7001_ $$aOlkina, Alexandra$$b147
000169401 7001_ $$aOñate-Ocaña, Luis$$b148
000169401 7001_ $$aOtero, Jaime$$b149
000169401 7001_ $$aOzen, Cihan$$b150
000169401 7001_ $$aPace, Ugo$$b151
000169401 7001_ $$aSão Julião, Guilherme Pagin$$b152
000169401 7001_ $$aPanaiotti, Lidiia$$b153
000169401 7001_ $$aPanis, Yves$$b154
000169401 7001_ $$aPapamichael, Demetris$$b155
000169401 7001_ $$aPark, Jason$$b156
000169401 7001_ $$aPatel, Swati$$b157
000169401 7001_ $$aPatrón Uriburu, Juan Carlos$$b158
000169401 7001_ $$aPera, Miguel$$b159
000169401 7001_ $$aPerez, Rodrigo O$$b160
000169401 7001_ $$aPetrov, Alexei$$b161
000169401 7001_ $$aPfeffer, Frank$$b162
000169401 7001_ $$aPhang, P Terry$$b163
000169401 7001_ $$aPoskus, Tomas$$b164
000169401 7001_ $$aPringle, Heather$$b165
000169401 7001_ $$aProud, David$$b166
000169401 7001_ $$aRaguz, Ivana$$b167
000169401 7001_ $$aRama, Nuno$$b168
000169401 7001_ $$aRasheed, Shahnawaz$$b169
000169401 7001_ $$aRaval, Manoj J$$b170
000169401 7001_ $$aRega, Daniela$$b171
000169401 7001_ $$aReissfelder, Christoph$$b172
000169401 7001_ $$aReyes Meneses, Juan Carlos$$b173
000169401 7001_ $$aRis, Frederic$$b174
000169401 7001_ $$aRiss, Stefan$$b175
000169401 7001_ $$aRodriguez-Zentner, Homero$$b176
000169401 7001_ $$aRoxburgh, Campbell S$$b177
000169401 7001_ $$aSaklani, Avanish$$b178
000169401 7001_ $$aSalido, Andrea Jiménez$$b179
000169401 7001_ $$aSammour, Tarik$$b180
000169401 7001_ $$aSaraste, Deborah$$b181
000169401 7001_ $$aSchneider, Martin$$b182
000169401 7001_ $$aSeishima, Ryo$$b183
000169401 7001_ $$aSekulic, Aleksandar$$b184
000169401 7001_ $$aSeppala, Toni$$b185
000169401 7001_ $$aSheahan, Kieran$$b186
000169401 7001_ $$aShine, Rebecca$$b187
000169401 7001_ $$aShlomina, Alexandra$$b188
000169401 7001_ $$aSica, Guiseppe S$$b189
000169401 7001_ $$aSingnomklao, Tongplaew$$b190
000169401 7001_ $$aSiragusa, Leandro$$b191
000169401 7001_ $$aSmart, Neil$$b192
000169401 7001_ $$aSolis, Alejandro$$b193
000169401 7001_ $$aSpinelli, Antonino$$b194
000169401 7001_ $$aStaiger, Roxane D$$b195
000169401 7001_ $$aStamos, Michael J$$b196
000169401 7001_ $$aSteele, Scott$$b197
000169401 7001_ $$aSunderland, Michael$$b198
000169401 7001_ $$aTan, Ker-Kan$$b199
000169401 7001_ $$aTanis, Pieter J$$b200
000169401 7001_ $$aTekkis, Paris$$b201
000169401 7001_ $$aTeklay, Biniam$$b202
000169401 7001_ $$aTengku, Sabrina$$b203
000169401 7001_ $$aJiménez-Toscano, Marta$$b204
000169401 7001_ $$aTsarkov, Petr$$b205
000169401 7001_ $$aTurina, Matthias$$b206
000169401 7001_ $$aUlrich, Alexis$$b207
000169401 7001_ $$aVailati, Bruna B$$b208
000169401 7001_ $$avan Harten, Meike$$b209
000169401 7001_ $$aVerhoef, Kees$$b210
000169401 7001_ $$aWarrier, Satish$$b211
000169401 7001_ $$aWexner, Steve$$b212
000169401 7001_ $$ade Wilt, Hans$$b213
000169401 7001_ $$aWeinberg, Benjamin A$$b214
000169401 7001_ $$aWells, Cameron$$b215
000169401 7001_ $$aWolthuis, Albert$$b216
000169401 7001_ $$aXynos, Evangelos$$b217
000169401 7001_ $$aYou, Nancy$$b218
000169401 7001_ $$aZakharenko, Alexander$$b219
000169401 7001_ $$aZeballos, Justino$$b220
000169401 7001_ $$aWinter, Des C$$b221
000169401 773__ $$0PERI:(DE-600)2701844-1$$a10.1001/jamasurg.2021.2380$$n9$$p865-874$$tJAMA surgery$$v156$$x2168-6254$$y2021
000169401 909CO $$ooai:inrepo02.dkfz.de:169401$$pVDB
000169401 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b87$$kDKFZ
000169401 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000169401 9130_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000169401 9141_ $$y2021
000169401 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJAMA SURG : 2019$$d2021-02-03
000169401 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bJAMA SURG : 2019$$d2021-02-03
000169401 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000169401 980__ $$ajournal
000169401 980__ $$aVDB
000169401 980__ $$aI:(DE-He78)C070-20160331
000169401 980__ $$aUNRESTRICTED