TY  - JOUR
AU  - Papadimitriou, Nikos
AU  - Gunter, Marc J
AU  - Murphy, Neil
AU  - Gicquiau, Audrey
AU  - Achaintre, David
AU  - Brezina, Stefanie
AU  - Gumpenberger, Tanja
AU  - Baierl, Andreas
AU  - Ose, Jennifer
AU  - Geijsen, Anne Jmr
AU  - van Roekel, Eline H
AU  - Gsur, Andrea
AU  - Gigic, Biljana
AU  - Habermann, Nina
AU  - Ulrich, Cornelia M
AU  - Kampman, Ellen
AU  - Weijenberg, Matty P
AU  - Ueland, Per-Magne
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Krogh, Vittorio
AU  - Bueno-de-Mesquita, Bas
AU  - Ardanaz, Eva
AU  - Travis, Ruth C
AU  - Schulze, Matthias B
AU  - Sánchez, Maria-José
AU  - Colorado-Yohar, Sandra M
AU  - Weiderpass, Elisabete
AU  - Scalbert, Augustin
AU  - Keski-Rahkonen, Pekka
TI  - Circulating tryptophan metabolites and risk of colon cancer: results from case-control and prospective cohort studies.
JO  - International journal of cancer
VL  - 149
IS  - 9
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2021-01487
SP  - 1659-1669
PY  - 2021
N1  - 2021 Nov 1;149(9):1659-1669
AB  - Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis, however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited. We studied associations of plasma tryptophan, serotonin, and kynurenine with colon cancer risk in two studies with cancer patients and controls, and in one prospective cohort: ColoCare Study (110 patients/153 controls), the Colorectal Cancer Study of Austria (CORSA; 46 patients/390 controls), and the European Prospective Investigation into Cancer and Nutrition (EPIC; 456 matched case-control pairs). Logistic regression was used to estimate odds ratios (OR) and 95
KW  - Tryptophan (Other)
KW  - colon cancer (Other)
KW  - kynurenine (Other)
KW  - plasma (Other)
KW  - serotonin (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34196970
DO  - DOI:10.1002/ijc.33725
UR  - https://inrepo02.dkfz.de/record/169665
ER  -