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@ARTICLE{Papadimitriou:169665,
      author       = {N. Papadimitriou and M. J. Gunter and N. Murphy and A.
                      Gicquiau and D. Achaintre and S. Brezina and T. Gumpenberger
                      and A. Baierl and J. Ose and A. J. Geijsen and E. H. van
                      Roekel and A. Gsur and B. Gigic and N. Habermann$^*$ and C.
                      M. Ulrich and E. Kampman and M. P. Weijenberg and P.-M.
                      Ueland and R. Kaaks$^*$ and V. Katzke$^*$ and V. Krogh and
                      B. Bueno-de-Mesquita and E. Ardanaz and R. C. Travis and M.
                      B. Schulze and M.-J. Sánchez and S. M. Colorado-Yohar and
                      E. Weiderpass and A. Scalbert and P. Keski-Rahkonen},
      title        = {{C}irculating tryptophan metabolites and risk of colon
                      cancer: results from case-control and prospective cohort
                      studies.},
      journal      = {International journal of cancer},
      volume       = {149},
      number       = {9},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-01487},
      pages        = {1659-1669},
      year         = {2021},
      note         = {2021 Nov 1;149(9):1659-1669},
      abstract     = {Dysregulation of tryptophan metabolism has been linked to
                      colorectal tumorigenesis, however, epidemiological studies
                      investigating tryptophan metabolites in relation to
                      colorectal cancer risk are limited. We studied associations
                      of plasma tryptophan, serotonin, and kynurenine with colon
                      cancer risk in two studies with cancer patients and
                      controls, and in one prospective cohort: ColoCare Study (110
                      patients/153 controls), the Colorectal Cancer Study of
                      Austria (CORSA; 46 patients/390 controls), and the European
                      Prospective Investigation into Cancer and Nutrition (EPIC;
                      456 matched case-control pairs). Logistic regression was
                      used to estimate odds ratios (OR) and $95\%$ confidence
                      intervals (CI) for colon cancer risk. Tryptophan was
                      inversely associated with colon cancer risk in ColoCare [OR
                      per 1-standard deviation (SD) = 0.44; $95\%$ CI, 0.31-0.64]
                      and EPIC (OR per 1-SD = 0.86; $95\%$ CI, 0.74-0.99).
                      Comparing detectable versus non-detectable levels, serotonin
                      was positively associated with colon cancer in CORSA
                      (OR = 6.39; $95\%$ CI, 3.61-11.3) and EPIC (OR = 2.03;
                      $95\%$ CI, 1.20-3.40). Kynurenine was inversely associated
                      with colon cancer in ColoCare (OR per 1-SD = 0.74; $95\%$
                      CI, 0.55-0.98), positively associated in CORSA (OR per
                      1-SD = 1.79; $95\%$ CI, 1.27-2.52), while no association
                      was observed in EPIC. The kynurenine-to-tryptophan ratio was
                      positively associated with colon cancer in ColoCare (OR per
                      1-SD = 1.38; $95\%$ CI, 1.03-1.84) and CORSA (OR per
                      1-SD = 1.44; $95\%$ CI, 1.06-1.96), but not in EPIC. These
                      results suggest that higher plasma tryptophan may be
                      associated with lower colon cancer risk, while increased
                      serotonin may be associated with a higher risk of colon
                      cancer. The kynurenine-to-tryptophan ratio may also reflect
                      altered tryptophan catabolism during colon cancer
                      development. This article is protected by copyright. All
                      rights reserved.},
      keywords     = {Tryptophan (Other) / colon cancer (Other) / kynurenine
                      (Other) / plasma (Other) / serotonin (Other)},
      cin          = {C120 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34196970},
      doi          = {10.1002/ijc.33725},
      url          = {https://inrepo02.dkfz.de/record/169665},
}