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@ARTICLE{IglesiasVzquez:169691,
      author       = {L. Iglesias-Vázquez and V. Arija and N. Aranda and E. K.
                      Aglago and A. J. Cross and M. B. Schulze and D. A. Quintana
                      Pacheco$^*$ and T. Kühn$^*$ and E. Weiderpass and R. Tumino
                      and D. Redondo-Sánchez and M. S. de Magistris and D. Palli
                      and E. Ardanaz and N. Laouali and E. Sonestedt and I. Drake
                      and L. Rizzolo and C. Santiuste and C. Sacerdote and R.
                      Quirós and P. Amiano and A. Agudo and P. Jakszyn},
      title        = {{F}actors associated with serum ferritin levels and iron
                      excess: results from the {EPIC}-{E}ur{G}ast study.},
      journal      = {European journal of nutrition},
      volume       = {61},
      issn         = {1436-6215},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-01498},
      pages        = {101–114},
      year         = {2022},
      note         = {61, pages 101–114 (2022)},
      abstract     = {Excess iron is involved in the development of
                      non-communicable diseases such as cancer, type 2 diabetes
                      and cardiovascular conditions. We aimed to describe the
                      prevalence of excess iron and its determinants in healthy
                      European adults.Sociodemographic, lifestyle, iron status,
                      dietary information, and HFE genotyping were obtained from
                      controls from the nested case-control study EPIC-EurGast
                      study. High sensitivity C-reactive protein (hsCRP) was
                      measured to address possible systemic inflammation.
                      Descriptive and multivariate analyses were used to assess
                      iron status and its determinants.Out of the 828 participants
                      (median age: 58.7 years), $43\%$ were females. Median serum
                      ferritin and prevalence of excess iron were 143.7 µg/L and
                      $35.2\%$ in males, respectively, and 77 µg/L and $20\%$ in
                      females, both increasing with latitude across Europe.
                      Prevalence of HFE C282Y mutation was significantly higher in
                      Northern and Central Europe (~ $11\%)$ than in the South
                      $(5\%).$ Overweight/obesity, age, and daily alcohol and heme
                      iron intake were independent determinants for iron status,
                      with sex differences even after excluding participants with
                      hsCRP > 5 mg/L. Obese males showed a greater consumption of
                      alcohol, total and red meat, and heme iron, compared with
                      those normal weight.Obesity, higher alcohol and heme iron
                      consumption were the main risk factors for excess iron in
                      males while only age was associated with iron overload in
                      females. Weight control and promoting healthy lifestyle may
                      help prevent iron overload, especially in obese people.
                      Further research is needed to clarify determinants of excess
                      iron in the healthy adult population, helping to reduce the
                      associated comorbidities.},
      keywords     = {EPIC (Other) / Excess iron (Other) / Iron overload (Other)
                      / Iron status (Other) / Serum ferritin (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34213605},
      doi          = {10.1007/s00394-021-02625-w},
      url          = {https://inrepo02.dkfz.de/record/169691},
}