guest ::
| Home > Publications database > Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study. > print |
| Home > Publications database > Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study. > print |
| 001 | 169691 | ||
| 005 | 20240229133652.0 | ||
| 024 | 7 | _ | |a 10.1007/s00394-021-02625-w |2 doi |
| 024 | 7 | _ | |a pmid:34213605 |2 pmid |
| 024 | 7 | _ | |a 0044-264X |2 ISSN |
| 024 | 7 | _ | |a 1435-1293 |2 ISSN |
| 024 | 7 | _ | |a 1436-6207 |2 ISSN |
| 024 | 7 | _ | |a 1436-6215 |2 ISSN |
| 024 | 7 | _ | |a altmetric:108586075 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01498 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Iglesias-Vázquez, Lucía |0 0000-0001-7131-4144 |b 0 |
| 245 | _ | _ | |a Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study. |
| 260 | _ | _ | |a Heidelberg |c 2022 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1643969593_9539 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 61, pages 101–114 (2022) |
| 520 | _ | _ | |a Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults.Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants.Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight.Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities. |
| 536 | _ | _ | |a 313 - Krebsrisikofaktoren und Prävention (POF4-313) |0 G:(DE-HGF)POF4-313 |c POF4-313 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a EPIC |2 Other |
| 650 | _ | 7 | |a Excess iron |2 Other |
| 650 | _ | 7 | |a Iron overload |2 Other |
| 650 | _ | 7 | |a Iron status |2 Other |
| 650 | _ | 7 | |a Serum ferritin |2 Other |
| 700 | 1 | _ | |a Arija, Victoria |0 0000-0002-1758-0975 |b 1 |
| 700 | 1 | _ | |a Aranda, Núria |0 0000-0001-9708-747X |b 2 |
| 700 | 1 | _ | |a Aglago, Elom K |0 0000-0002-0442-3284 |b 3 |
| 700 | 1 | _ | |a Cross, Amanda J |0 0000-0002-0893-2377 |b 4 |
| 700 | 1 | _ | |a Schulze, Matthias B |0 0000-0002-0830-5277 |b 5 |
| 700 | 1 | _ | |a Quintana Pacheco, Daniel Antonio |0 P:(DE-He78)2b1939dd3b00e62eeea7798367576c30 |b 6 |
| 700 | 1 | _ | |a Kühn, Tilman |0 P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe |b 7 |u dkfz |
| 700 | 1 | _ | |a Weiderpass, Elisabete |0 0000-0003-2237-0128 |b 8 |
| 700 | 1 | _ | |a Tumino, Rosario |0 0000-0003-2666-414X |b 9 |
| 700 | 1 | _ | |a Redondo-Sánchez, Daniel |0 0000-0001-9986-915X |b 10 |
| 700 | 1 | _ | |a de Magistris, Maria Santucci |b 11 |
| 700 | 1 | _ | |a Palli, Domenico |0 0000-0002-5558-2437 |b 12 |
| 700 | 1 | _ | |a Ardanaz, Eva |0 0000-0001-8434-2013 |b 13 |
| 700 | 1 | _ | |a Laouali, Nasser |0 0000-0002-8532-456X |b 14 |
| 700 | 1 | _ | |a Sonestedt, Emily |0 0000-0002-0747-4562 |b 15 |
| 700 | 1 | _ | |a Drake, Isabel |0 0000-0002-6500-6310 |b 16 |
| 700 | 1 | _ | |a Rizzolo, Lucía |b 17 |
| 700 | 1 | _ | |a Santiuste, Carmen |b 18 |
| 700 | 1 | _ | |a Sacerdote, Carlotta |0 0000-0002-8008-5096 |b 19 |
| 700 | 1 | _ | |a Quirós, Ramón |b 20 |
| 700 | 1 | _ | |a Amiano, Pilar |0 0000-0003-3986-7026 |b 21 |
| 700 | 1 | _ | |a Agudo, Antonio |0 0000-0001-9900-5677 |b 22 |
| 700 | 1 | _ | |a Jakszyn, Paula |0 0000-0003-0672-8847 |b 23 |
| 773 | _ | _ | |a 10.1007/s00394-021-02625-w |0 PERI:(DE-600)1463312-7 |p 101–114 |t European journal of nutrition |v 61 |y 2022 |x 1436-6215 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:169691 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)2b1939dd3b00e62eeea7798367576c30 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-313 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Krebsrisikofaktoren und Prävention |x 0 |
| 913 | 0 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-313 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Cancer risk factors and prevention |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a DEAL Springer |0 StatID:(DE-HGF)3002 |2 StatID |d 2021-01-27 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-27 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-27 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-27 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-19 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-19 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-19 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-19 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-19 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EUR J NUTR : 2021 |d 2022-11-19 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-19 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-19 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-19 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |d 2022-11-19 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2022-11-19 |
| 920 | 1 | _ | |0 I:(DE-He78)C020-20160331 |k C020 |l C020 Epidemiologie von Krebs |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)C020-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|