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@ARTICLE{Amitay:169698,
      author       = {E. Amitay$^*$ and T. Niedermaier$^*$ and A. Gies$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{R}isk {F}actors of {I}nadequate {B}owel {P}reparation for
                      {S}creening {C}olonoscopy.},
      journal      = {Journal of Clinical Medicine},
      volume       = {10},
      number       = {12},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-01505},
      pages        = {2740},
      year         = {2021},
      note         = {#EA:C070#LA:C070#},
      abstract     = {The success of a colonoscopy in detecting and removing
                      pre-cancerous and cancerous lesions depends heavily on the
                      quality of bowel preparation. Despite efforts, $20-44\%$ of
                      colonoscopy participants have an inadequate bowel
                      preparation. We aimed to assess and compare risk factors for
                      inadequate bowel preparation and for the presence of
                      advanced colorectal neoplasms in routine screening practice.
                      In this cross-sectional study, among 8125 participants of
                      screening colonoscopy in Germany with a comprehensive
                      assessment of sociodemographic factors, lifestyle and
                      medical history, we examined factors associated with
                      inadequate bowel preparation and with findings of advanced
                      neoplasms using adjusted log-binomial regression models.
                      Among the identified risk factors assessed, three factors
                      were identified that were significantly associated with
                      inadequate bowel preparation: age ≥ 70 years (adjusted
                      prevalence ratios, aPR, 1.50 $95\%CI$ 1.31-1.71), smoking
                      (aPR 1.29 $95\%CI$ 1.11-1.50) and abdominal symptoms (aPR
                      1.14 $95\%CI$ 1.02-1.27). The same risk factors were also
                      associated with the prevalence of advanced neoplasms in our
                      study (aPR 1.72, 1.62 and 1.44, respectively). The risk
                      factors associated with inadequate bowel preparation in this
                      study were also associated with a higher risk for advanced
                      neoplasms. Inadequate bowel preparation for colonoscopy
                      might lead to missed colorectal cancer (CRC) precursors and
                      the late diagnosis of CRC. People at high risk of advanced
                      neoplasms are in particular need of enhanced bowel
                      preparation.},
      keywords     = {bowel preparation (Other) / cancer screening (Other) /
                      colonoscopy (Other) / colorectal neoplasms (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34205800},
      doi          = {10.3390/jcm10122740},
      url          = {https://inrepo02.dkfz.de/record/169698},
}