%0 Journal Article
%A Tan, Aaron C
%A Bagley, Stephen J
%A Wen, Patrick Y
%A Lim, Michael
%A Platten, Michael
%A Colman, Howard
%A Ashley, David M
%A Wick, Wolfgang
%A Chang, Susan M
%A Galanis, Evanthia
%A Mansouri, Alireza
%A Khagi, Simon
%A Mehta, Minesh P
%A Heimberger, Amy B
%A Puduvalli, Vinay K
%A Reardon, David A
%A Sahebjam, Solmaz
%A Simes, John
%A Antonia, Scott J
%A Berry, Don
%A Khasraw, Mustafa
%T Systematic review of combinations of targeted or immunotherapy in advanced solid tumors.
%J Journal for ImmunoTherapy of Cancer
%V 9
%N 7
%@ 2051-1426
%C London
%I BioMed Central
%M DKFZ-2021-01518
%P e002459
%D 2021
%X With rapid advances in our understanding of cancer, there is an expanding number of potential novel combination therapies, including novel-novel combinations. Identifying which combinations are appropriate and in which subpopulations are among the most difficult questions in medical research. We conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic review of trials of novel-novel combination therapies involving immunotherapies or molecular targeted therapies in advanced solid tumors. A MEDLINE search was conducted using a modified Cochrane Highly Sensitive Search Strategy for published clinical trials between July 1, 2017, and June 30, 2020, in the top-ranked medical and oncology journals. Trials were evaluated according to a criterion adapted from previously published Food and Drug Administration guidance and other key considerations in designing trials of combinations. This included the presence of a strong biological rationale, the use of a new established or emerging predictive biomarker prospectively incorporated into the clinical trial design, appropriate comparator arms of monotherapy or supportive external data sources and a primary endpoint demonstrating a clinically meaningful benefit. Of 32 identified trials, there were 11 (34
%K clinical trials as topic (Other)
%K combination (Other)
%K drug therapy (Other)
%K immunotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34215688
%R 10.1136/jitc-2021-002459
%U https://inrepo02.dkfz.de/record/169711