%0 Journal Article
%A Müller, Jana
%A Weiler, Markus
%A Schneeweiss, Andreas
%A Haag, Georg Martin
%A Steindorf, Karen
%A Wick, Wolfgang
%A Wiskemann, Joachim
%T Preventive effect of sensorimotor exercise and resistance training on chemotherapy-induced peripheral neuropathy: a randomised-controlled trial.
%J British journal of cancer
%V 125
%N 7
%@ 1532-1827
%C Edinburgh
%I Nature Publ. Group
%M DKFZ-2021-01539
%P 955-965
%D 2021
%Z #EA:D120#LA:D120# / 2021 Sep;125(7):955-965
%X Chemotherapy-induced peripheral neuropathy (CIPN) is a common, unpleasant and usually long-lasting side effect of neurotoxic chemotherapeutic agents. This study aimed to investigate the preventive potential of sensorimotor- (SMT) and resistance training (RT) on CIPN.Patients (N = 170) were randomised to SMT, RT or usual care (UC). Both exercise groups trained 3×/week for a total of 105 min/week during neurotoxic chemotherapy (mean length: 20 weeks). Before and 3 weeks after neurotoxic chemotherapy, CIPN signs/symptoms were assessed via Total Neuropathy Score (TNSr; primary endpoint) and EORTC QLQ-CIPN15 questionnaire. In addition, balance (centre of pressure), muscle strength (isokinetic), quality of life (QoL, EORTC QLQ-C30) and relative chemotherapy dose intensity (RDI) were investigated. The follow-up period covered 6 months after the end of chemotherapy.Intention-to-treat analyses (N = 159) revealed no differences regarding CIPN signs/symptoms. Exploratory per-protocol analyses (minimum training attendance rate 67
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34226683
%R 10.1038/s41416-021-01471-1
%U https://inrepo02.dkfz.de/record/169734