TY  - JOUR
AU  - Müller, Jana
AU  - Weiler, Markus
AU  - Schneeweiss, Andreas
AU  - Haag, Georg Martin
AU  - Steindorf, Karen
AU  - Wick, Wolfgang
AU  - Wiskemann, Joachim
TI  - Preventive effect of sensorimotor exercise and resistance training on chemotherapy-induced peripheral neuropathy: a randomised-controlled trial.
JO  - British journal of cancer
VL  - 125
IS  - 7
SN  - 1532-1827
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2021-01539
SP  - 955-965
PY  - 2021
N1  - #EA:D120#LA:D120# / 2021 Sep;125(7):955-965
AB  - Chemotherapy-induced peripheral neuropathy (CIPN) is a common, unpleasant and usually long-lasting side effect of neurotoxic chemotherapeutic agents. This study aimed to investigate the preventive potential of sensorimotor- (SMT) and resistance training (RT) on CIPN.Patients (N = 170) were randomised to SMT, RT or usual care (UC). Both exercise groups trained 3×/week for a total of 105 min/week during neurotoxic chemotherapy (mean length: 20 weeks). Before and 3 weeks after neurotoxic chemotherapy, CIPN signs/symptoms were assessed via Total Neuropathy Score (TNSr; primary endpoint) and EORTC QLQ-CIPN15 questionnaire. In addition, balance (centre of pressure), muscle strength (isokinetic), quality of life (QoL, EORTC QLQ-C30) and relative chemotherapy dose intensity (RDI) were investigated. The follow-up period covered 6 months after the end of chemotherapy.Intention-to-treat analyses (N = 159) revealed no differences regarding CIPN signs/symptoms. Exploratory per-protocol analyses (minimum training attendance rate 67
LB  - PUB:(DE-HGF)16
C6  - pmid:34226683
DO  - DOI:10.1038/s41416-021-01471-1
UR  - https://inrepo02.dkfz.de/record/169734
ER  -