% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mller:169734,
      author       = {J. Müller$^*$ and M. Weiler and A. Schneeweiss and G. M.
                      Haag and K. Steindorf$^*$ and W. Wick$^*$ and J. Wiskemann},
      title        = {{P}reventive effect of sensorimotor exercise and resistance
                      training on chemotherapy-induced peripheral neuropathy: a
                      randomised-controlled trial.},
      journal      = {British journal of cancer},
      volume       = {125},
      number       = {7},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2021-01539},
      pages        = {955-965},
      year         = {2021},
      note         = {#EA:D120#LA:D120# / 2021 Sep;125(7):955-965},
      abstract     = {Chemotherapy-induced peripheral neuropathy (CIPN) is a
                      common, unpleasant and usually long-lasting side effect of
                      neurotoxic chemotherapeutic agents. This study aimed to
                      investigate the preventive potential of sensorimotor- (SMT)
                      and resistance training (RT) on CIPN.Patients (N = 170) were
                      randomised to SMT, RT or usual care (UC). Both exercise
                      groups trained 3×/week for a total of 105 min/week during
                      neurotoxic chemotherapy (mean length: 20 weeks). Before and
                      3 weeks after neurotoxic chemotherapy, CIPN signs/symptoms
                      were assessed via Total Neuropathy Score (TNSr; primary
                      endpoint) and EORTC QLQ-CIPN15 questionnaire. In addition,
                      balance (centre of pressure), muscle strength (isokinetic),
                      quality of life (QoL, EORTC QLQ-C30) and relative
                      chemotherapy dose intensity (RDI) were investigated. The
                      follow-up period covered 6 months after the end of
                      chemotherapy.Intention-to-treat analyses (N = 159) revealed
                      no differences regarding CIPN signs/symptoms. Exploratory
                      per-protocol analyses (minimum training attendance rate
                      $67\%;$ N = 89) indicated that subjectively perceived
                      sensory symptoms in the feet increased less during
                      chemotherapy in the adherent exercisers (pooled group:
                      SMT+RT) than in the UC group (-8.3 points (-16.1 to -0.4); P
                      = 0.039, ES = 1.27). Furthermore, adherent exercisers
                      received a higher RDI (96.6 ± 4.8 vs. 92.2 ± 9.4; P =
                      0.045), showed a better course of muscular strength (+20.8
                      Nm (11.2-30.4); P < 0.001, ES = 0.57) and QoL (+12.9 points
                      (3.9-21.8); P = 0.005, ES = 0.64). During follow-up, CIPN
                      signs/symptoms persisted in all groups.This study
                      demonstrates that SMT and/or RT alleviate subjectively
                      perceived sensory CIPN symptoms in the feet and other
                      clinically relevant cancer therapy-related outcomes, if an
                      appropriate training stimulus is achieved.NCT02871284.},
      cin          = {D120 / C110 / B320},
      ddc          = {610},
      cid          = {I:(DE-He78)D120-20160331 / I:(DE-He78)C110-20160331 /
                      I:(DE-He78)B320-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34226683},
      doi          = {10.1038/s41416-021-01471-1},
      url          = {https://inrepo02.dkfz.de/record/169734},
}