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@ARTICLE{Bieber:169757,
      author       = {K. Bieber and M. Günter$^*$ and K. A. Pasquevich and S.
                      Autenrieth$^*$},
      title        = {{S}ystemic bacterial infections affect dendritic cell
                      development and function.},
      journal      = {International journal of medical microbiology},
      volume       = {311},
      number       = {6},
      issn         = {1438-4221},
      address      = {München},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-01540},
      pages        = {151517},
      year         = {2021},
      note         = {#LA:F171#},
      abstract     = {Dendritic cells (DCs) are critical in host defense against
                      infection. DC depletion is an early event in the course of
                      sepsis that may impair the host defense mechanisms. Here, we
                      addressed whether DC depletion and dysfunction are
                      pathogen-independent, mediated via pattern recognition
                      receptors, and are due to impaired DC development upon
                      systemic infection with the Gram-negative bacterium
                      Escherichia coli and the Gram-positive pathogen
                      Staphylococcus aureus. Infection with E. coli and S. aureus
                      led to reduced numbers of splenic DC subsets and of DC
                      progenitors in the bone marrow (BM) with this effect
                      persisting significantly longer in mice infected with S.
                      aureus than with E. coli. The reduction of DC subsets and
                      their progenitors was mainly TLR-independent as was the
                      infection-induced monopoiesis. Moreover, de novo DC
                      development was impaired in mice infected with S. aureus,
                      and BM cells from E. coli or S. aureus infected mice favored
                      macrophage differentiation in vitro. As a consequence of
                      reduced DC numbers and their reduced expression of MHC II
                      less CD4+ and CD8+ T cells, especially Th1 and IFN-γ
                      producing CD8+ T cells, could be detected in S. aureus
                      compared to E. coli infected mice. These differences are
                      reflected in the rapid killing of E. coli as opposed to an
                      increase in bacterial load in S. aureus. In summary, our
                      study supports the idea that systemic bacterial infections
                      generally affect the number and development of DCs and
                      thereby the T cell responses, but the magnitude is
                      pathogen-dependent.},
      keywords     = {Dendritic cells (Other) / Development (Other) / Escherichia
                      coli (Other) / Infection (Other) / Innate immune defense
                      (Other) / Monocytes (Other) / Staphylococcus aureus (Other)
                      / TLR (Other)},
      cin          = {F171},
      ddc          = {610},
      cid          = {I:(DE-He78)F171-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34233227},
      doi          = {10.1016/j.ijmm.2021.151517},
      url          = {https://inrepo02.dkfz.de/record/169757},
}