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000169805 037__ $$aDKFZ-2021-01559
000169805 041__ $$aEnglish
000169805 082__ $$a610
000169805 1001_ $$00000-0002-7701-9733$$aCastelli, Lucia$$b0
000169805 245__ $$aSleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy.
000169805 260__ $$aNew York,NY$$bSpringer$$c2022
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000169805 500__ $$a2022 Jan;30(1):167-176
000169805 520__ $$aSleep problems reported by hematological cancer patients are usually linked to higher levels of cancer-related fatigue. Although the awareness of sleep problems in solid cancer patients is rising, there has been less attention to the issue in hematological cancer patients. The present study assesses the differences in sleep by comparing physical activity and fatigue levels among hematological cancer patients during the onset of chemotherapy. Furthermore, it investigates the relationship between sleep, physical activity, and fatigue through mediation analysis.The recruited sample consists of 58 newly diagnosed hematological cancer patients (47.1 ± 15.4 yrs; 51.7% males). Subjects completed questionnaires assessing sleep (PSQI), physical activity (visual analogue scale), fatigue (MFI-20), anxiety, depression (HADS), and quality of life (EORTC QLQ-C30) within two weeks from starting treatment.The sample reported more sleep problems in comparison to the German population norm. The classification as good (ca 25%) or bad sleepers (ca 75%) showed less frequent physical activity (p = .04), higher fatigue (p = .032), anxiety (p = .003), depression (p = .011) and pain (p = .011) in bad sleepers. The mediation analysis revealed significant indirect effects of sleep on fatigue through physical activity habits.This study highlights the combined action of sleep problems and physical activity on fatigue during the onset of induction chemotherapy. These two parameters could represent meaningful intervention targets to improve a patient's status during chemotherapy.The study was registered on the WHO trial register (DRKS00007824).
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000169805 650_7 $$2Other$$aFatigue
000169805 650_7 $$2Other$$aHematological cancer
000169805 650_7 $$2Other$$aLeukemia
000169805 650_7 $$2Other$$aPhysical activity
000169805 650_7 $$2Other$$aSleep
000169805 7001_ $$aElter, Thomas$$b1
000169805 7001_ $$aWolf, Florian$$b2
000169805 7001_ $$aWatson, Matthew$$b3
000169805 7001_ $$aSchenk, Alexander$$b4
000169805 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b5$$udkfz
000169805 7001_ $$00000-0003-1786-8853$$aBloch, Wilhelm$$b6
000169805 7001_ $$aHallek, Michael$$b7
000169805 7001_ $$aJoisten, Niklas$$b8
000169805 7001_ $$aZimmer, Philipp$$b9
000169805 773__ $$0PERI:(DE-600)1463166-0$$a10.1007/s00520-021-06377-5$$n1$$p167-176$$tSupportive care in cancer$$v30$$x1433-7339$$y2022
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