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@ARTICLE{Porta:169831,
      author       = {M. Porta and M. Gasull and J. Pumarega and H. Kiviranta and
                      P. Rantakokko and O. Raaschou-Nielsen and I. A. Bergdahl and
                      T. M. Sandanger and A. Agudo and C. Rylander and T. H. Nøst
                      and C. Donat-Vargas and D. Aune and A. K. Heath and L.
                      Cirera and F. Goñi-Irigoyen and J. Alguacil and À.
                      Giménez-Robert and A. Tjønneland and M. Sund and K.
                      Overvad and F. R. Mancini and V. Rebours and M.-C.
                      Boutron-Ruault and R. Kaaks$^*$ and M. B. Schulze and A.
                      Trichopoulou and D. Palli and S. Grioni and R. Tumino and A.
                      Naccarati and S. Panico and R. Vermeulen and J. R. Quirós
                      and M. Rodríguez-Barranco and S. M. Colorado-Yohar and
                      M.-D. Chirlaque and E. Ardanaz and N. Wareham and T. Key and
                      M. Johansson and N. Murphy and P. Ferrari and I. Huybrechts
                      and V. Chajes and C. A. Gonzalez and B. B. de-Mesquita and
                      M. Gunter and E. Weiderpass and E. Riboli and E. J. Duell
                      and V. Katzke$^*$ and P. Vineis},
      title        = {{P}lasma concentrations of persistent organic pollutants
                      and pancreatic cancer risk.},
      journal      = {International journal of epidemiology},
      volume       = {51},
      number       = {2},
      issn         = {1464-3685},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2021-01575},
      pages        = {479-490},
      year         = {2022},
      note         = {2022 May 9;51(2):479-490},
      abstract     = {Findings and limitations of previous studies on persistent
                      organic pollutants (POPs) and pancreatic cancer risk support
                      conducting further research in prospective cohorts.We
                      conducted a prospective case-control study nested within the
                      European Prospective Investigation into Cancer and Nutrition
                      (EPIC) cohort. Participants were 513 pancreatic cancer cases
                      and 1020 matched controls. Concentrations of 22 POPs were
                      measured in plasma collected at baseline.Some associations
                      were observed at higher concentrations of p, p'-DDT,
                      trans-nonachlor, β-hexachlorocyclohexane and the sum of six
                      organochlorine pesticides and of 16 POPs. The odds ratio
                      (OR) for the upper quartile of trans-nonachlor was 1.55
                      $(95\%$ confidence interval 1.06-2.26; P for trend = 0.025).
                      Associations were stronger in the groups predefined as most
                      valid (participants having fasted >6 h, with microscopic
                      diagnostic confirmation, normal weight, and never smokers),
                      and as most relevant (follow-up ≥10 years). Among
                      participants having fasted >6 h, the ORs were relevant for
                      10 of 11 exposures. Higher ORs were also observed among
                      cases with microscopic confirmation than in cases with a
                      clinical diagnosis, and among normal-weight participants
                      than in the rest of participants. Among participants with a
                      follow-up ≥10 years, estimates were higher than in
                      participants with a shorter follow-up (for trans-nonachlor:
                      OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall,
                      trans-nonachlor, three PCBs and the two sums of POPs were
                      the exposures most clearly associated with pancreatic cancer
                      risk.Individually or in combination, most of the 22 POPs
                      analysed did not or only moderately increased the risk of
                      pancreatic cancer.},
      subtyp        = {Review Article},
      keywords     = {Pancreatic cancer (Other) / biomarkers (Other) /
                      environmental health (Other) / methods (Other) / persistent
                      organic pollutants (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34259837},
      doi          = {10.1093/ije/dyab115},
      url          = {https://inrepo02.dkfz.de/record/169831},
}