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@ARTICLE{Reibelt:169836,
      author       = {A. Reibelt and M. Mayinger and K. J. Borm and S. E.
                      Combs$^*$ and M. N. Duma},
      title        = {{N}euroanatomical changes seen in {MRI} in patients with
                      cerebral metastasized breast cancer after radiotherapy.},
      journal      = {Tumori journal},
      volume       = {108},
      number       = {5},
      issn         = {2038-2529},
      address      = {Thousand Oaks, Calif.},
      publisher    = {Sage Publishing},
      reportid     = {DKFZ-2021-01580},
      pages        = {486-494},
      year         = {2022},
      note         = {2022 Oct;108(5):486-494},
      abstract     = {To quantify neuroanatomical changes using magnetic
                      resonance imaging (MRI) in patients with cerebral
                      metastasized breast cancer after brain radiotherapy
                      (RT).Fifteen patients with breast cancer with brain
                      metastases who underwent whole brain RT (WBR), radiosurgery
                      (RS), and/or hypofractionated stereotactic treatment (STX)
                      were examined at four time points (TPs). A total of 48 MRIs
                      were available: prior to RT (TP1), 5-8 months after RT
                      (TP2), 9-11 months after RT (TP3), and >20 months after RT
                      (TP4). Using automatic segmentation, 25 subcortical
                      structures were analyzed. Patients were split into three
                      groups: STX (receiving STX and RS), RS (receiving RS only),
                      and WBR (receiving WBR at least once). After testing for a
                      normal distribution for all values using the
                      Kolmogorov-Smirnov test, a two-sided paired t test was used
                      to analyze volumetric changes. For those values that were
                      not normally distributed, the nonparametric Mann-Whitney
                      test was employed.The left cerebellum white matter (p =
                      0.028), the right pallidum (p = 0.038), and the left
                      thalamus (p = 0.039) significantly increased at TP2 compared
                      to TP1. The third ventricle increased at all TPs (p =
                      0.034-0.046). The left choroid plexus increased at TP3 (p =
                      0.037) compared to TP1. The left lateral ventricle increased
                      at TP3 (p = 0.012) and TP4 (p = 0.027). Total gray matter
                      showed a trend of volume decline in STX and WBR groups.These
                      findings indicate that alterations in the volume of
                      subcortical structures may act as a sensitive parameter when
                      evaluating neuroanatomical changes and brain atrophy due to
                      radiotherapy. Differences observed for patients who received
                      STX and WBR, but not those treated with RS, need to be
                      validated further.},
      keywords     = {FreeSurfer (Other) / Neuroanatomical changes (Other) /
                      brain radiotherapy (Other) / cerebral metastasized breast
                      cancer (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34256653},
      doi          = {10.1177/03008916211031301},
      url          = {https://inrepo02.dkfz.de/record/169836},
}