%0 Journal Article
%A Glöss, Stefanie
%A Jurmeister, Philipp
%A Thieme, Anne
%A Schmid, Simone
%A Cai, Wei Y
%A Serrette, Rene N
%A Perner, Sven
%A Ribbat-Idel, Julika
%A Pagenstecher, Axel
%A Bläker, Hendrik
%A Keber, Ursula
%A Stadelmann, Christine
%A Zechel, Sabrina
%A Johann, Pascal D
%A Hasselblatt, Martin
%A Paulus, Werner
%A Thomas, Christian
%A Dohmen, Hildegard
%A Baumhoer, Daniel
%A Frank, Stephan
%A Agaimy, Abbas
%A Schüller, Ulrich
%A Vasudevaraja, Varshini
%A Snuderl, Matija
%A Liu, Cheng Z
%A Pfister, David G
%A Jungbluth, Achim A
%A Ghossein, Ronald A
%A Xu, Bin
%A Capper, David
%A Dogan, Snjezana
%T IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome.
%J The American journal of surgical pathology
%V 45
%N 9
%@ 0147-5185
%C [S.l.]
%I Ovid
%M DKFZ-2021-01583
%P 1190-1204
%D 2021
%Z 2021 Sep 1;45(9):1190-1204
%X IDH2 R172 mutations occur in sinonasal undifferentiated carcinoma (SNUC), large-cell neuroendocrine carcinoma (LCNEC), sinonasal adenocarcinomas, and olfactory neuroblastoma (ONB). We performed a clinical, pathologic, and genetic/epigenetic analysis of a large IDH2-mutated sinonasal tumor cohort to explore their distinct features. A total 165 sinonasal/skull base tumors included 40 IDH2 mutants studied by light microscopy, immunohistochemistry, and genome-wide DNA methylation, and 125 IDH2 wild-type tumors used for comparison. Methylation profiles were analyzed by unsupervised hierarchical clustering, t-distributed stochastic neighbor embedding dimensionality reduction and assessed for copy number alterations (CNA). Thirty-nine histologically assessable cases included 25 (64.1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34265800
%R 10.1097/PAS.0000000000001697
%U https://inrepo02.dkfz.de/record/169840