TY  - JOUR
AU  - Glöss, Stefanie
AU  - Jurmeister, Philipp
AU  - Thieme, Anne
AU  - Schmid, Simone
AU  - Cai, Wei Y
AU  - Serrette, Rene N
AU  - Perner, Sven
AU  - Ribbat-Idel, Julika
AU  - Pagenstecher, Axel
AU  - Bläker, Hendrik
AU  - Keber, Ursula
AU  - Stadelmann, Christine
AU  - Zechel, Sabrina
AU  - Johann, Pascal D
AU  - Hasselblatt, Martin
AU  - Paulus, Werner
AU  - Thomas, Christian
AU  - Dohmen, Hildegard
AU  - Baumhoer, Daniel
AU  - Frank, Stephan
AU  - Agaimy, Abbas
AU  - Schüller, Ulrich
AU  - Vasudevaraja, Varshini
AU  - Snuderl, Matija
AU  - Liu, Cheng Z
AU  - Pfister, David G
AU  - Jungbluth, Achim A
AU  - Ghossein, Ronald A
AU  - Xu, Bin
AU  - Capper, David
AU  - Dogan, Snjezana
TI  - IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome.
JO  - The American journal of surgical pathology
VL  - 45
IS  - 9
SN  - 0147-5185
CY  - [S.l.]
PB  - Ovid
M1  - DKFZ-2021-01583
SP  - 1190-1204
PY  - 2021
N1  - 2021 Sep 1;45(9):1190-1204
AB  - IDH2 R172 mutations occur in sinonasal undifferentiated carcinoma (SNUC), large-cell neuroendocrine carcinoma (LCNEC), sinonasal adenocarcinomas, and olfactory neuroblastoma (ONB). We performed a clinical, pathologic, and genetic/epigenetic analysis of a large IDH2-mutated sinonasal tumor cohort to explore their distinct features. A total 165 sinonasal/skull base tumors included 40 IDH2 mutants studied by light microscopy, immunohistochemistry, and genome-wide DNA methylation, and 125 IDH2 wild-type tumors used for comparison. Methylation profiles were analyzed by unsupervised hierarchical clustering, t-distributed stochastic neighbor embedding dimensionality reduction and assessed for copy number alterations (CNA). Thirty-nine histologically assessable cases included 25 (64.1
LB  - PUB:(DE-HGF)16
C6  - pmid:34265800
DO  - DOI:10.1097/PAS.0000000000001697
UR  - https://inrepo02.dkfz.de/record/169840
ER  -