| 001 | 169840 | ||
| 005 | 20240229133657.0 | ||
| 024 | 7 | _ | |a 10.1097/PAS.0000000000001697 |2 doi |
| 024 | 7 | _ | |a pmid:34265800 |2 pmid |
| 024 | 7 | _ | |a 0147-5185 |2 ISSN |
| 024 | 7 | _ | |a 1532-0979 |2 ISSN |
| 024 | 7 | _ | |a altmetric:109621430 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01583 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Glöss, Stefanie |0 P:(DE-He78)766063bc14996d73b7b17b5017c8fcba |b 0 |u dkfz |
| 245 | _ | _ | |a IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome. |
| 260 | _ | _ | |a [S.l.] |c 2021 |b Ovid |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1642167948_13476 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Sep 1;45(9):1190-1204 |
| 520 | _ | _ | |a IDH2 R172 mutations occur in sinonasal undifferentiated carcinoma (SNUC), large-cell neuroendocrine carcinoma (LCNEC), sinonasal adenocarcinomas, and olfactory neuroblastoma (ONB). We performed a clinical, pathologic, and genetic/epigenetic analysis of a large IDH2-mutated sinonasal tumor cohort to explore their distinct features. A total 165 sinonasal/skull base tumors included 40 IDH2 mutants studied by light microscopy, immunohistochemistry, and genome-wide DNA methylation, and 125 IDH2 wild-type tumors used for comparison. Methylation profiles were analyzed by unsupervised hierarchical clustering, t-distributed stochastic neighbor embedding dimensionality reduction and assessed for copy number alterations (CNA). Thirty-nine histologically assessable cases included 25 (64.1%) SNUC, 8 (20.5%) LCNEC, 2 (5.1%) poorly differentiated adenocarcinomas, 1 (2.7%) ONB, and 3 (7.7%) IDH2-mutated tumors with ONB features. All cases were high-grade showing necrosis (82.4%), prominent nucleoli (88.9%), and median 21 mitoses/10 HPFs. AE1/AE3 and/or CAM 5.2 were positive in all and insulinoma-associated protein 1 (INSM1) in 80% cases. All IDH2 mutants formed one distinct group by t-distributed stochastic neighbor embedding dimensionality reduction separating from all IDH2 wild-type tumors. There was no correlation between methylation clusters and histopathologic diagnoses. Recurrent CNA included 1q gain (79.3%), 17p loss (75.9%), and 17q gain (58.6%). No CNA differences were observed between SNUC and LCNEC. IDH2 mutants showed better disease-specific survival than SMARCB1-deficient (P=0.027) and IDH2 wild-type carcinomas overall (P=0.042). IDH2-mutated sinonasal tumors are remarkably homogeneous at the molecular level and distinct from IDH2 wild-type sinonasal malignancies. Biology of IDH2-mutated sinonasal tumors might be primarily defined by their unique molecular fingerprint rather than by their respective histopathologic diagnoses. |
| 536 | _ | _ | |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312) |0 G:(DE-HGF)POF4-312 |c POF4-312 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 700 | 1 | _ | |a Jurmeister, Philipp |b 1 |
| 700 | 1 | _ | |a Thieme, Anne |0 P:(DE-He78)21f693ba604e9286be3b25068b440d08 |b 2 |u dkfz |
| 700 | 1 | _ | |a Schmid, Simone |b 3 |
| 700 | 1 | _ | |a Cai, Wei Y |b 4 |
| 700 | 1 | _ | |a Serrette, Rene N |b 5 |
| 700 | 1 | _ | |a Perner, Sven |b 6 |
| 700 | 1 | _ | |a Ribbat-Idel, Julika |b 7 |
| 700 | 1 | _ | |a Pagenstecher, Axel |b 8 |
| 700 | 1 | _ | |a Bläker, Hendrik |b 9 |
| 700 | 1 | _ | |a Keber, Ursula |b 10 |
| 700 | 1 | _ | |a Stadelmann, Christine |b 11 |
| 700 | 1 | _ | |a Zechel, Sabrina |b 12 |
| 700 | 1 | _ | |a Johann, Pascal D |0 P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8 |b 13 |u dkfz |
| 700 | 1 | _ | |a Hasselblatt, Martin |b 14 |
| 700 | 1 | _ | |a Paulus, Werner |b 15 |
| 700 | 1 | _ | |a Thomas, Christian |b 16 |
| 700 | 1 | _ | |a Dohmen, Hildegard |b 17 |
| 700 | 1 | _ | |a Baumhoer, Daniel |b 18 |
| 700 | 1 | _ | |a Frank, Stephan |b 19 |
| 700 | 1 | _ | |a Agaimy, Abbas |b 20 |
| 700 | 1 | _ | |a Schüller, Ulrich |b 21 |
| 700 | 1 | _ | |a Vasudevaraja, Varshini |b 22 |
| 700 | 1 | _ | |a Snuderl, Matija |b 23 |
| 700 | 1 | _ | |a Liu, Cheng Z |b 24 |
| 700 | 1 | _ | |a Pfister, David G |b 25 |
| 700 | 1 | _ | |a Jungbluth, Achim A |b 26 |
| 700 | 1 | _ | |a Ghossein, Ronald A |b 27 |
| 700 | 1 | _ | |a Xu, Bin |b 28 |
| 700 | 1 | _ | |a Capper, David |0 P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c |b 29 |u dkfz |
| 700 | 1 | _ | |a Dogan, Snjezana |b 30 |
| 773 | _ | _ | |a 10.1097/PAS.0000000000001697 |g Vol. Publish Ahead of Print |0 PERI:(DE-600)2029143-7 |n 9 |p 1190-1204 |t The American journal of surgical pathology |v 45 |y 2021 |x 0147-5185 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:169840 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)766063bc14996d73b7b17b5017c8fcba |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)21f693ba604e9286be3b25068b440d08 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 13 |6 P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 29 |6 P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-312 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Funktionelle und strukturelle Genomforschung |x 0 |
| 913 | 0 | _ | |a DE-HGF |b Programmungebundene Forschung |l ohne Programm |1 G:(DE-HGF)POF3-890 |0 G:(DE-HGF)POF3-899 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-800 |4 G:(DE-HGF)POF |v ohne Topic |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a Allianz-Lizenz |0 StatID:(DE-HGF)0410 |2 StatID |d 2021-01-30 |w ger |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2021-01-30 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-30 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2021-01-30 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b AM J SURG PATHOL : 2019 |d 2021-01-30 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2021-01-30 |
| 920 | 1 | _ | |0 I:(DE-He78)BE01-20160331 |k BE01 |l DKTK BE zentral |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)BE01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|
guest ::