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@ARTICLE{Hoffmann:169863,
      author       = {E. Hoffmann and F. Paulsen and P. Schaedle and D. Zips$^*$
                      and C. Gani$^*$ and H.-G. Rammensee$^*$ and C.
                      Gouttefangeas$^*$ and F. Eckert$^*$},
      title        = {{R}adiotherapy planning parameters correlate with changes
                      in the peripheral immune status of patients undergoing
                      curative radiotherapy for localized prostate cancer.},
      journal      = {Cancer immunology immunotherapy},
      volume       = {71},
      issn         = {1432-0851},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-01597},
      pages        = {541–552},
      year         = {2022},
      note         = {71, pages 541–552 (2022)},
      abstract     = {The influence of radiotherapy on patient immune cell
                      subsets has been established by several groups. Following a
                      previously published analysis of immune changes during and
                      after curative radiotherapy for prostate cancer, this
                      analysis focused on describing correlations of changes of
                      immune cell subsets with radiation treatment parameters.For
                      13 patients treated in a prospective trial with radiotherapy
                      to the prostate region (primary analysis) and five patients
                      treated with radiotherapy to prostate and pelvic nodal
                      regions (exploratory analysis), already published immune
                      monitoring data were correlated with clinical data as well
                      as radiation planning parameters such as clinical target
                      volume (CTV) and volumes receiving 20 Gy (V20) for newly
                      contoured volumes of pelvic blood vessels and bone
                      marrow.Most significant changes among immune cell subsets
                      were observed at the end of radiotherapy. In contrast,
                      correlations of age and CD8+ subsets (effector and memory
                      cells) were observed early during and 3 months after
                      radiotherapy. Ratios of T cells and T cell proliferation
                      compared to baseline correlated with CTV. Early changes in
                      regulatory T cells (Treg cells) and CD8+ effector T cells
                      correlated with V20 of blood vessels and bone
                      volumes.Patient age as well as radiotherapy planning
                      parameters correlated with immune changes during
                      radiotherapy. Larger irradiated volumes seem to correlate
                      with early suppression of anti-cancer immunity. For immune
                      cell analysis during normofractionated radiotherapy and
                      correlations with treatment planning parameters, different
                      time points should be looked at in future
                      projects.NCT01376674, 20.06.2011.},
      keywords     = {DVH (Other) / IMRT (Other) / Immune status (Other) /
                      Localized (Other) / Prostate cancer (Other) / T cells
                      (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34269847},
      doi          = {10.1007/s00262-021-03002-6},
      url          = {https://inrepo02.dkfz.de/record/169863},
}