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@ARTICLE{Hemminki:169872,
      author       = {K. Hemminki$^*$ and A. Försti$^*$ and A. Hemminki},
      title        = {{S}urvival in colon and rectal cancers in {F}inland and
                      {S}weden through 50 years.},
      journal      = {BMJ open gastroenterology},
      volume       = {8},
      number       = {1},
      issn         = {2054-4774},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DKFZ-2021-01606},
      pages        = {e000644},
      year         = {2021},
      abstract     = {Global survival studies have shown favourable development
                      in colon and rectal cancers but few studies have considered
                      extended periods or covered populations for which medical
                      care is essentially free of charge.We analysed colon and
                      rectal cancer survival in Finland and Sweden over a 50-year
                      period (1967-2016) using data from the Nordcan database. In
                      addition to the standard 1-year and 5-year survival rates,
                      we calculated the difference between these as a novel
                      measure of how well survival was maintained between years 1
                      and 5.Relative 1-year and 5-year survival rates have
                      developed favourably without major shifts for men and women
                      in both countries. For Finnish men, 1-year survival in colon
                      cancer increased from $50\%$ to $82\%,$ and for rectal
                      cancer from $62\%$ to $85\%.$ The Swedish survival was a few
                      per cent unit better for 1-year survival but for 5-year
                      survival the results were equal. Survival of female patients
                      for both cancers was somewhat better than survival in men
                      through 50 years. Overall the survival gains were higher in
                      the early compared with the late follow-up periods, and were
                      the smallest in the last 10 years. The difference between
                      1-year and 5-year survival in colon cancer was essentially
                      unchanged over the 50-year period while in rectal cancer
                      there was a large improvement.The gradual positive
                      development in survival suggests a contribution by many
                      small improvements rather than single breakthroughs. The
                      improvement in 5-year survival in colon cancer was almost
                      entirely driven by improvement in 1-year survival while in
                      rectal cancer the positive development extended to survival
                      past year 1, probably due to successful curative treatments.
                      The current challenges are to reinvigorate the apparently
                      stalled positive development and to extend them to old
                      patients. For colon cancer, survival gains need to be
                      extended past year 1 of diagnosis.},
      keywords     = {colorectal cancer (Other) / diagnostic and therapeutic
                      endoscopy (Other) / health service research (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34272211},
      doi          = {10.1136/bmjgast-2021-000644},
      url          = {https://inrepo02.dkfz.de/record/169872},
}