TY  - JOUR
AU  - Niedermaier, Tobias
AU  - Heisser, Thomas
AU  - Gies, Anton
AU  - Guo, Feng
AU  - Amitay, Efrat
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - To what extent is male excess risk of advanced colorectal neoplasms explained by known risk factors? Results from a large German screening population.
JO  - International journal of cancer
VL  - 149
IS  - 11
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2021-01621
SP  - 1877-1886
PY  - 2021
N1  - #EA:C070#LA:C070# / 2021 Dec 1;149(11):1877-1886
AB  - Colorectal cancer (CRC) incidence and prevalence of its precursors are substantially higher among males than among females in most countries but the reasons for the male excess risk are incompletely understood. We aimed to assess to what extent it is explained by known risk factors. Prevalence of advanced neoplasia (AN, i.e. CRC or advanced adenoma) and CRC risk and preventive factors were ascertained among 15,985 participants of screening colonoscopy aged 55-79 years in Germany. Logistic regression was used to calculate odds ratios (ORs) for the association between male sex and AN with and without adjustment for known risk and preventive factors. In age-adjusted comparisons, men had twofold increased risk for AN compared to women (OR=1.98, 95
KW  - colorectal neoplasia (Other)
KW  - distal colon (Other)
KW  - male sex (Other)
KW  - prevalence (Other)
KW  - proximal colon (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34278571
DO  - DOI:10.1002/ijc.33742
UR  - https://inrepo02.dkfz.de/record/169887
ER  -