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000169931 0247_ $$2doi$$a DOI: 10.1007/978-3-030-62658-7_3 
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000169931 041__ $$aEnglish
000169931 082__ $$a570
000169931 1001_ $$0P:(DE-He78)362c70c115d46aa1a548be003315f3bf$$aAsokan, Sahana$$b0$$eFirst author$$udkfz
000169931 245__ $$aCXCL8 Signaling in the Tumor Microenvironment.
000169931 260__ $$a[Heidelberg]$$bSpringer$$c2021
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000169931 520__ $$aThe tumor microenvironment represents a dynamic and complex cellular network involving intricate communications between the tumor and highly heterogeneous groups of cells, including tumor-supporting immune and inflammatory cells, cancer-associated fibroblasts, endothelial cells, tumor-associated macrophages, adipose cells, and pericytes. Associated with a variety of growth factors, chemokines, cytokines, and other signaling molecules, the interaction between the tumor microenvironment and the tumor cells empowers aggressiveness of tumor by enhancing its survivability. CXCL8 (also known as Interleukin 8), a multifunctional proinflammatory chemokine that was initially classified as a neutrophil chemoattractant, recently has been found to be a key contributor in tumorigenesis. The upregulation of CXCL8 at the tumor invasion front in several human cancers suggests its interplay between the tumor and its microenvironment rendering tumor progression by enhancing angiogenesis, tumor genetic diversity, survival, proliferation, immune escape, metastasis, and multidrug resistance. The autocrine and paracrine modulation of CXCL8 via the chemokine receptors CXCR1/2 promotes several intracellular signaling cascades that fosters tumor-associated inflammation, reprogramming, epithelial-mesenchymal transition, and neovascularization. Hence, decrypting the regulatory/signaling cascades of CXCL8 and its downstream effects may harbor prognostic clinical prospects of a tumor microenvironment-oriented cancer therapeutics.
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000169931 650_7 $$2Other$$aAngiogenesis
000169931 650_7 $$2Other$$aAngiogenic switch
000169931 650_7 $$2Other$$aAutocrine signaling
000169931 650_7 $$2Other$$aCXCL8
000169931 650_7 $$2Other$$aCXCR1/2
000169931 650_7 $$2Other$$aCancer
000169931 650_7 $$2Other$$aChemokines
000169931 650_7 $$2Other$$aEpithelial-mesenchymal transition
000169931 650_7 $$2Other$$aInterleukin-8
000169931 650_7 $$2Other$$aIntracellular signaling cascade
000169931 650_7 $$2Other$$aInvasion front
000169931 650_7 $$2Other$$aMetastasis
000169931 650_7 $$2Other$$aSurvival
000169931 650_7 $$2Other$$aTumor microenvironment
000169931 650_7 $$2Other$$aTumor-related inflammation
000169931 650_7 $$2NLM Chemicals$$aInterleukin-8
000169931 650_7 $$2NLM Chemicals$$aReceptors, Interleukin-8A
000169931 650_7 $$2NLM Chemicals$$aReceptors, Interleukin-8B
000169931 650_2 $$2MeSH$$aEndothelial Cells
000169931 650_2 $$2MeSH$$aHumans
000169931 650_2 $$2MeSH$$aInterleukin-8
000169931 650_2 $$2MeSH$$aReceptors, Interleukin-8A
000169931 650_2 $$2MeSH$$aReceptors, Interleukin-8B
000169931 650_2 $$2MeSH$$aTumor Microenvironment
000169931 7001_ $$0P:(DE-He78)b11ccde1801d45d32a6a60f7b396d7dc$$aBandapalli, Obul Reddy$$b1$$eLast author$$udkfz
000169931 773__ $$0PERI:(DE-600)2385266-5$$a10.1007/978-3-030-62658-7_3$$p25-39$$tAdvances in experimental medicine and biology$$v1302$$x0065-2598$$y2021
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000169931 9141_ $$y2021
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