%0 Journal Article
%A O'Connor, Tracy Lynn
%A Heikenwälder, Mathias
%T CCL2 in the Tumor Microenvironment.
%J Advances in experimental medicine and biology
%V 1302
%@ 0065-2598
%C [Heidelberg]
%I Springer
%M DKFZ-2021-01638
%@ 978-3-030-62657-0 (print)
%P 1-14
%D 2021
%Z #EA:F180#LA:F180#
%X The C-C motif chemokine ligand 2 (CCL2) is a crucial mediator of immune cell recruitment during microbial infections and tissue damage. CCL2 is also frequently overexpressed in cancer cells and other cells in the tumor microenvironment, and a large body of evidence indicates that high CCL2 levels are associated with more aggressive malignancies, a higher probability of metastasis, and poorer outcomes in a wide range of cancers. CCL2 plays a role in recruiting tumor-associated macrophages (TAMs), which adopt a pro-tumorigenic phenotype and support cancer cell survival, facilitate tumor cell invasion, and promote angiogenesis. CCL2 also has direct, TAM-independent effects on tumor cells and the tumor microenvironment, including recruitment of other myeloid subsets and non-myeloid cells, maintaining an immunosuppressive environment, stimulating tumor cell growth and motility, and promoting angiogenesis. CCL2 also plays important roles in the metastatic cascade, such as creating a pre-metastatic niche in distant organs and promoting tumor cell extravasation across endothelia. Due to its many roles in tumorigenesis and metastatic processes, the CCL2-CCR2 signaling axis is currently being pursued as a potential therapeutic target for cancer.
%K Cell Line, Tumor
%K Chemokine CCL2: genetics
%K Chemokines
%K Ligands
%K Receptors, CCR2: genetics
%K Tumor Microenvironment
%K Angiogenesis (Other)
%K CCL2 (Other)
%K CCR2 (Other)
%K Cancer (Other)
%K Extravasation (Other)
%K Immunity (Other)
%K Immunosuppression (Other)
%K Invasion (Other)
%K MCP-1 (Other)
%K Macrophage (Other)
%K Metastasis (Other)
%K Microenvironment (Other)
%K NFκB (Other)
%K TAM (Other)
%K Tumor (Other)
%K Chemokine CCL2 (NLM Chemicals)
%K Chemokines (NLM Chemicals)
%K Ligands (NLM Chemicals)
%K Receptors, CCR2 (NLM Chemicals)
%F PUB:(DE-HGF)3 ; PUB:(DE-HGF)16
%9 BookJournal Article
%$ pmid:34286437
%R 10.1007/978-3-030-62658-7_1
%U https://inrepo02.dkfz.de/record/169932