TY  - JOUR
AU  - O'Connor, Tracy Lynn
AU  - Heikenwälder, Mathias
TI  - CCL2 in the Tumor Microenvironment.
JO  - Advances in experimental medicine and biology
VL  - 1302
SN  - 0065-2598
CY  - [Heidelberg]
PB  - Springer
M1  - DKFZ-2021-01638
SN  - 978-3-030-62657-0 (print)
SP  - 1-14
PY  - 2021
N1  - #EA:F180#LA:F180#
AB  - The C-C motif chemokine ligand 2 (CCL2) is a crucial mediator of immune cell recruitment during microbial infections and tissue damage. CCL2 is also frequently overexpressed in cancer cells and other cells in the tumor microenvironment, and a large body of evidence indicates that high CCL2 levels are associated with more aggressive malignancies, a higher probability of metastasis, and poorer outcomes in a wide range of cancers. CCL2 plays a role in recruiting tumor-associated macrophages (TAMs), which adopt a pro-tumorigenic phenotype and support cancer cell survival, facilitate tumor cell invasion, and promote angiogenesis. CCL2 also has direct, TAM-independent effects on tumor cells and the tumor microenvironment, including recruitment of other myeloid subsets and non-myeloid cells, maintaining an immunosuppressive environment, stimulating tumor cell growth and motility, and promoting angiogenesis. CCL2 also plays important roles in the metastatic cascade, such as creating a pre-metastatic niche in distant organs and promoting tumor cell extravasation across endothelia. Due to its many roles in tumorigenesis and metastatic processes, the CCL2-CCR2 signaling axis is currently being pursued as a potential therapeutic target for cancer.
KW  - Cell Line, Tumor
KW  - Chemokine CCL2: genetics
KW  - Chemokines
KW  - Ligands
KW  - Receptors, CCR2: genetics
KW  - Tumor Microenvironment
KW  - Angiogenesis (Other)
KW  - CCL2 (Other)
KW  - CCR2 (Other)
KW  - Cancer (Other)
KW  - Extravasation (Other)
KW  - Immunity (Other)
KW  - Immunosuppression (Other)
KW  - Invasion (Other)
KW  - MCP-1 (Other)
KW  - Macrophage (Other)
KW  - Metastasis (Other)
KW  - Microenvironment (Other)
KW  - NFκB (Other)
KW  - TAM (Other)
KW  - Tumor (Other)
KW  - Chemokine CCL2 (NLM Chemicals)
KW  - Chemokines (NLM Chemicals)
KW  - Ligands (NLM Chemicals)
KW  - Receptors, CCR2 (NLM Chemicals)
LB  - PUB:(DE-HGF)3 ; PUB:(DE-HGF)16
C6  - pmid:34286437
DO  - DOI:10.1007/978-3-030-62658-7_1
UR  - https://inrepo02.dkfz.de/record/169932
ER  -